ArticleThe Journal of comparative neurology2019
Central and peripheral innervation patterns of defined axial motor units in larval zebrafish.
Article in The Journal of comparative neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Distinct developmental dynamics of opposing persistent currents shape motoneuron firing during motor maturation of zebrafish.The Journal of physiology · 2026Article
- Spatially ordered recruitment of fast muscles in accordance with movement strengths in larval zebrafish.Zoological letters · 2025Article
- Novel Transgenic Zebrafish Lines to Study the CHRNA3-B4-A5 Gene Cluster.Developmental neurobiology · 2025Article
- Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis.bioRxiv : the preprint server for biology · 2024Article
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- Neuroprotective gap-junction-mediated bystander transformations in the adult zebrafish spinal cord after injury.Nature communications · 2024Article
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- Spinal Basis of Direction Control during Locomotion in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Development of a high-throughput tailored imaging method in zebrafish to understand and treat neuromuscular diseases.Frontiers in molecular neuroscience · 2022Article
- Establishing the Molecular and Functional Diversity of Spinal Motoneurons.Advances in neurobiology · 2022Article
- Spinal V1 neurons inhibit motor targets locally and sensory targets distally.Current biology : CB · 2021Article
- Illuminating ALS Motor Neurons With Optogenetics in Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord.Science (New York, N.Y.) · 2020Article
- Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Dual function of epaxial musculature for swimming and suction feeding in largemouth bass.Proceedings. Biological sciences · 2020Article
- Hindbrain and Spinal Cord Contributions to the Cutaneous Sensory Innervation of the Larval Zebrafish Pectoral Fin.Frontiers in neuroanatomy · 2020Article
- Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish.Nature communications · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
Spinal motor neurons and the peripheral muscle fibers they innervate form discrete motor units that execute movements of varying force and speed. Subsets of spinal motor neurons also exhibit axon collaterals that influence motor output centrally. Here, we have used in vivo imaging to anatomically characterize the central and peripheral innervation patterns of axial motor units in larval zebrafish. Using early born "primary" motor neurons and their division of epaxial and hypaxial muscle into four distinct quadrants as a reference, we define three distinct types of later born "secondary" motor units. The largest is "m-type" units, which innervate deeper fast-twitch muscle fibers via medial nerves. Next in size are "ms-type" secondaries, which innervate superficial fast-twitch and slow fibers via medial and septal nerves, followed by "s-type" units, which exclusively innervate superficial slow muscle fibers via septal nerves. All types of secondaries innervate up to four axial quadrants. Central axon collaterals are found in subsets of primaries based on soma position and predominantly in secondary fast-twitch units (m, ms) with increasing likelihood based on number of quadrants innervated. Collaterals are labeled by synaptophysin-tagged fluorescent proteins, but not PSD95, consistent with their output function. Also, PSD95 dendrite labeling reveals that larger motor units receive more excitatory synaptic input. Collaterals are largely restricted to the neuropil, however, perisomatic connections are observed between motor units. These observations suggest that recurrent interactions are dominated by motor neurons recruited during stronger movements and set the stage for functional investigations of recurrent motor circuitry in larval zebrafish.
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