Evidence map›Paper›PMID 30919791›Full record

ArticleThe British journal of psychiatry : the journal of mental science2019

Neurocognitive functioning in community youth with suicidal ideation: gender and pubertal effects.

Ran Barzilay, Monica E Calkins, Tyler M Moore, Rhonda C Boyd, Jason D Jones, Tami D Benton, Maria A Oquendo, Ruben C Gur, Raquel E Gur

Abstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Association between family history of suicide attempt and neurocognitive functioning in community youth.Journal of child psychology and psychiatry, and allied disciplines · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Suicide Ideation and Neurocognition Among 9- and 10-Year Old Children in the Adolescent Brain Cognitive Development (ABCD) Study.Archives of suicide research : official journal of the International Academy for Suicide Research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ran BarzilayResearch Scientist, Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine; and Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, USA.ORCID https://orcid.org/0000-0002-3247-2331
Monica E CalkinsAssociate Professor, Neuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Tyler M MooreResearch Associate, Neuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Rhonda C BoydAssociate Professor, Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, USA.
Jason D JonesResearch Scientist, Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, USA.
Tami D BentonAssociate Professor, Chair of the Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, USA.
Maria A OquendoProfessor, Chair of the Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Ruben C GurProfessor, Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine; and Director of Neuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Raquel E GurProfessor, Director of Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine; and Neuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.

Funding

Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M
NMDA Receptor Hypofunction in the Amygdala of Schizophrenia PatientsP50MH096891 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BILKER, WARREN B. · 2012 to 2016
$10.6M
Multimodal brain maturation indices modulating psychopathology and neurocognitionR01MH107235 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RUBEN C. · 2015 to 2017
$1.5M
NIMH NIH HHS P50 MH096891NIMH NIH HHS R01 MH107235NIMH NIH HHS RC2 MH089983
6 · The paper itself

Abstract

backgroundAlthough there are extensive data on clinical psychopathology in youth with suicidal ideation, data are lacking regarding their neurocognitive function.

aimsTo characterise the cognitive profile of youth with suicidal ideation in a community sample and evaluate gender differences and pubertal status effects.

methodParticipants (N = 6151, age 11-21 years, 54.9% females) from the Philadelphia Neurodevelopmental Cohort, a non-help-seeking community sample, underwent detailed clinical evaluation. Cognitive phenotyping included executive functioning, episodic memory, complex reasoning and social cognitive functioning. We compared participants with suicidal ideation (N = 672) and without suicidal ideation (N = 5479). Regression models were employed to evaluate differences in cognitive performance and functional level, with gender and pubertal status as independent variables. Models controlled for lifetime depression or general psychopathology, and for covariates including age and socioeconomic status.

resultsYouth with suicidal ideation showed greater psychopathology, poorer level of function but better overall neurocognitive performance. Greater functional impairment was observed in females with suicidal ideation (suicidal ideation × gender interaction, t = 3.091, P = 0.002). Greater neurocognition was associated with suicidal ideation post-puberty (suicidal ideation × puberty interaction, t = 3.057, P = 0.002). Exploratory analyses of specific neurocognitive domains showed that suicidal ideation-associated cognitive superiority was more prominent in post-pubertal males compared with females (Cohen's d = 0.32 and d = 0.11, respectively) across all cognitive domains.

conclusionsSuicidal ideation was associated with poorer functioning yet better cognitive performance, especially in post-pubertal males, as measured by a comprehensive cognitive battery. Findings point to gender and pubertal-status specificity in the relationship between suicidal ideation, cognition and function in youth. DECLARATION OF INTEREST: R.B. serves on the scientific board and reports stock ownership in 'Taliaz Health', with no conflict of interest relevant to this work. M.A.O. receives royalties for the commercial use of the Columbia-Suicide Severity Rating Scale from the Research Foundation for Mental Hygiene. Her family owns stock in Bristol-Myers Squibb. All other authors declare no potential conflict of interest.

Indexed as

Adolescent DevelopmentExecutive FunctionSuicidal IdeationThinkingAdolescentChildCognitive DysfunctionCohort StudiesFemaleHumansLogistic ModelsMalePhiladelphiaPsychiatric Status Rating ScalesPsychopathologyRisk Factorscognitiondevelopmental psychopathologygender differencesSuicidal ideation

Identifiers

PMID30919791
PMCPMC6868531

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.