Evidence map›Paper›PMID 30919524›Full record

ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2019

Sex-specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block-associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy.

Norman C Wang, Ure Mezu-Chukwu, Evan C Adelstein, Andrew D Althouse, Michael S Sharbaugh, Sandeep K Jain, Alaa A Shalaby, Andrew H Voigt, Samir Saba

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Sex-specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block-associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Norman C WangHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.ORCID 0000-0002-8388-2146
Ure Mezu-ChukwuHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Evan C AdelsteinAlbany Medical Center, Albany, New York.
Andrew D AlthouseHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Michael S SharbaughHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Sandeep K JainHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Alaa A ShalabyHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Andrew H VoigtHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Samir SabaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
University of Pittsburgh Medical Center · USAlbany Medical Center Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex differences in clinical outcomes for left bundle branch block (LBBB)-associated idiopathic nonischemic cardiomyopathy (NICM) after cardiac resynchronization therapy (CRT) are not well described.

methodsA retrospective cohort study at an academic medical center included subjects with LBBB-associated idiopathic NICM who received CRT. Cox regression analyses estimated the hazard ratios (HRs) between sex and clinical outcomes.

resultsIn 123 total subjects (mean age 62 years, mean initial left ventricular ejection fraction 22.8%, 76% New York Heart Association class III, and 98% CRT-defibrillators), 55 (45%) were men and 68 (55%) were women. The median follow-up time after CRT was 72.4 months. Similar risk for adverse clinical events (heart failure hospitalization, appropriate implantable cardioverter-defibrillator shock, appropriate antitachycardia pacing therapy, ventricular assist device implantation, heart transplantation, and death) was observed between men and women (HR, 1.20; 95% confidence interval [CI] 0.57-2.51; p = 0.63). This persisted in multivariable analyses. Men and women had similar risk for all-cause mortality in univariable analysis, but men had higher risk in the final multivariable model that adjusted for age at diagnosis, QRS duration, and left ventricular end-diastolic dimension index (HR, 4.55; 95% CI, 1.26-16.39; p = 0.02). The estimated 5-year mortality was 9.5% for men and 6.9% for women.

conclusionsIn LBBB-associated idiopathic NICM, men have higher risk for all-cause mortality after CRT when compared to women.

Indexed as

Bundle-Branch BlockCardiac Resynchronization TherapyCardiomyopathiesCohort StudiesDefibrillators, ImplantableElectric CountershockFemaleHeart TransplantationHumansKaplan-Meier EstimateMaleMiddle AgedRetrospective StudiesSex FactorsTreatment Outcomecardiac resynchronization therapyclinical outcomesleft bundle branch blocknonischemic cardiomyopathysex-specific

Identifiers

PMID30919524
PMCPMC6931705
OpenAlexW2927662152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.