Evidence map›Paper›PMID 30919154›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Effectiveness of exercise-based rehabilitation on functional capacity and quality of life in head and neck cancer patients receiving chemo-radiotherapy.

Stephen Rajan Samuel, Arun G Maiya, Donald J Fernandes, Vasudeva Guddattu, P U Prakash Saxena, Jestina Rachel Kurian, Po-Ju Lin, Karen M Mustian

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 82 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 12 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04082793 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Comparison of Photobiomodulation Therapy and Sonophoresis in Improving Tempomandibular Joint Mobility and Quality of Life Among Head and Neck Cancer Survivors (PBMT-S Trial): A Triple-Blind, Randomized Controlled Trial.

TypeinterventionalSponsorAsir John SamuelRan2020 to 2021Enrolled48ConditionsHead and Neck Cancer, TrismusArmsPhotobiomodulation therapy with mandibular exercises, Sonophoresis with mandibular exercises
NCT04617678 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

A Comprehensive Approach to Head and Neck Cancer Prehabilitation

TypeinterventionalSponsorSanford HealthRan2021 to 2026Enrolled80ConditionsCancer of Head and NeckArmsPrehabilitation Program
NCT04679233 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy

TypeinterventionalSponsorVanderbilt UniversityRan2021 to 2021Enrolled0ConditionsHead and Neck Neoplasm, RadiotherapyArmsPrescription aerobic exercise
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 12 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Effects of exercise on head and neck cancer surgery: a systematic review of randomized controlled trials.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. The effects of aerobic and resistance training across eight cancer types: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  3. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  4. Pooled it
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  6. Effect of exercise across the head and neck cancer continuum: a systematic review of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  7. Pooled it
  8. Physical rehabilitation for the management of cancer-related fatigue during cytotoxic treatment: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  13. Trial
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  16. Feasibility of a comprehensive supervised exercise program during and after treatment of head and neck cancer: a mixed-methods study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Stephen Rajan SamuelDepartment of Physiotherapy, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.ORCID http://orcid.org/0000-0002-5636-2620
Arun G MaiyaDepartment of Physiotherapy, School of Allied Health Sciences, Manipal Academy of Higher Education, Manipal, India. arun.maiya@manipal.edu.
Donald J FernandesDepartment of Radiotherapy and Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Vasudeva GuddattuDepartment of Statistics, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India.
P U Prakash SaxenaDepartment of Radiotherapy and Oncology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.
Jestina Rachel KurianDepartment of Medical Education, Kasturba Medical College,Mangalore, Manipal Academy of Higher Education, Manipal, India.
Po-Ju LinDepartment of Surgery, Wilmot Cancer Institute, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, New York, USA.
Karen M MustianDepartment of Surgery, Wilmot Cancer Institute, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, New York, USA.
Manipal Academy of Higher Education · INUniversity of Rochester Medical Center · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Yoga Versus CBT-I for Insomnia in Cancer Survivors and Biobehavioral MechanismsR01CA181064 · NCI · UNIVERSITY OF ROCHESTER · PI MUSTIAN, KAREN M. · 2014 to 2019
$3.1M
NCI NIH HHS R01 CA181064NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

purposeFatigue, decreased functionality, and impaired quality of life are some of the most common adverse outcomes of chemo-radiotherapy (CRT). Head and neck cancers (HNC) affect more than half a million individuals globally and its treatment takes a heavy toll on the patient, often affecting their speech, swallowing, and respiratory functions, and as a result they often develop fatigue, depression, and physical inactivity. The purpose of this study was to evaluate the effectiveness of exercise-based rehabilitation on functional capacity, quality of life, fatigue, hemoglobin, and platelet counts in patients with HNC on CRT. PATIENTS AND

methodsA randomized controlled trial was conducted on 148 patients with head and neck cancer undergoing CRT to evaluate the effectiveness of exercise on functional capacity measured by the 6-min walk test, quality of life measured by the Medical Outcomes Survey Short Form 36 v2 questionnaire, fatigue by the NCCN (0-10) scale, hemoglobin, and platelets. The control group received standard physical activity recommendations while the exercise group received a structured exercise program of aerobic and active resistance exercises for a period of 11 weeks.

resultsThere was a significant improvement in the functional capacity (p < 0.001), quality of life (p < 0.001), and prevention of worsening of fatigue (p < 0.001) in the exercise group. The blood parameters did not show a significant difference between the control group and the exercise group.

conclusionOur results elucidate that an 11-week structured exercise program for HNC patients receiving CRT helps in improving their functional capacity and quality of life. It also prevents deterioration of fatigue levels in the exercise group.

Indexed as

ChemoradiotherapyAdultDepressionExerciseExercise TherapyExercise ToleranceFatigueFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedQuality of LifeSurveys and QuestionnairesCancer rehabilitationChemo-radiotherapyExerciseFunctional capacityHead and neck cancerQuality of life

Identifiers

PMID30919154
PMCPMC6728220
OpenAlexW2914732198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.