Evidence map›Paper›PMID 30919143›Full record

ReviewCurrent oncology reports2019

The Impact of Obesity on Breast Cancer Diagnosis and Treatment.

Kyuwan Lee, Laura Kruper, Christina M Dieli-Conwright, Joanne E Mortimer

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current oncology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06360809 (Prehabilitation Exercise Program in Breast Cancer), which is not on this map. Cited by 200 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 11 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06360809 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Prehabilitation Exercise Program in Breast Cancer: Effects on Quality of Life and Tumor Microenvironment (PEP_BC)

TypeinterventionalSponsorInstitut Nacional d'Educacio Fisica de CatalunyaRan2024 to 2025Enrolled76ConditionsBreast CancerArmsPrehabilitation exercise program
3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 11 syntheses or guidelines pooled it, 399 citations in OpenAlex.

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140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kyuwan LeeDivision of Biokinesiology and Physical Therapy, University of Southern California (USC), 1540 E. Alcazar Street, CHP 155, Los Angeles, CA, 90033, USA.
Laura KruperDepartment of Surgical Oncology, City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, CA, 91010, USA.
Christina M Dieli-ConwrightDivision of Biokinesiology and Physical Therapy, University of Southern California (USC), 1540 E. Alcazar Street, CHP 155, Los Angeles, CA, 90033, USA.
Joanne E MortimerDepartment of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer, 1500 E Duarte Rd, Duarte, CA, 91010, USA. jmortimer@coh.org.
City of Hope · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewObesity is a recognized risk factor for the development of breast cancer and recurrence even when patients are treated appropriately. We reviewed the literature that addresses the impact of obesity on diagnosis and the individual therapeutic interventions, and present a summary of the findings. RECENT

findingsCompared to non-obese women with breast cancer, obese women with breast cancer have a worse disease-free and overall survival despite appropriate local and systemic therapies. In brief, obese breast cancer patients experience more complications related to surgery, radiation, and chemotherapy. Further, obese patients are at increased risk for local recurrence compared to normal-weight women. Similarly, systemic chemotherapy is less effective, even when dosed appropriately on the basis of actual weight. Overall, endocrine therapy is less effective in obese women, and there is a suggestion that aromatase inhibitors may be selectively less effective than tamoxifen. Obese women are less likely to undergo breast reconstruction than normal-weight women, and those who do have surgery experience more surgical complications. The efficacy of cancer treatments is significantly lower in obese breast cancer survivors, posing greater challenges in patient care and disease management in this patient population. Further investigations are warranted to assess the effects on treatment outcomes and optimize therapeutic mechanisms in order to successfully target breast cancer associated with obesity.

Indexed as

Antineoplastic Agents, HormonalBreast NeoplasmsEarly Detection of CancerFemaleHumansObesityPhysician-Patient RelationsPostoperative ComplicationsRadiotherapyTreatment OutcomeAntineoplastic Agents, HormonalBreast cancerClinical outcomesDiagnosisObesityTreatment

Identifiers

PMID30919143
PMCPMC6437123
OpenAlexW2924917805

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.