ArticleBrain structure & function2019
Posterior thalamic nucleus axon terminals have different structure and functional impact in the motor and somatosensory vibrissal cortices.
Article in Brain structure & function, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Anatomy of Cerebro-cerebellar Circuits in Motor Control.Cerebellum (London, England) · 2026Review
- Medullary and C3-C4 propriospinal pathways underlying mammalian forelimb movement control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pathway-Specific Ultrastructure of Thalamocortical Synapses in Mouse Somatosensory Area S2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Involvement of Thalamic Nuclei in Schizophrenia Patients with and Without Auditory Verbal Hallucinations: A Brain Morphometry Study.Brain sciences · 2025Article
- Thalamocortical feedback selectively controls pyramidal neuron excitability.Nature communications · 2025Article
- Absence seizures: Update on signaling mechanisms and networks.Epilepsia open · 2025Article
- High-Resolution Tractography Protocol to Investigate the Pathways between Human Mediodorsal Thalamic Nucleus and Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Translating single-neuron axonal reconstructions into meso-scale connectivity statistics in the mouse somatosensory thalamus.Frontiers in neuroinformatics · 2023Article
- Benchmarking of tools for axon length measurement in individually-labeled projection neurons.PLoS computational biology · 2021Article
- Exploring communication between the thalamus and cognitive control-related functional networks in the cerebral cortex.Cognitive, affective & behavioral neuroscience · 2021Article
- Parallel and Serial Sensory Processing in Developing Primary Somatosensory and Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Higher-Order Thalamic Encoding of Somatosensory Patterns and Bilateral Events.Frontiers in neural circuits · 2021Article
- Corticothalamic Pathways From Layer 5: Emerging Roles in Computation and Pathology.Frontiers in neural circuits · 2021Review
- Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse.eLife · 2020Article
- Superior colliculus modulates cortical coding of somatosensory information.Nature communications · 2020Article
- Area-Specific Synapse Structure in Branched Posterior Nucleus Axons Reveals a New Level of Complexity in Thalamocortical Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Distinctive Spatial and Laminar Organization of Single Axons from Lateral Pulvinar in the Macaque.Vision (Basel, Switzerland) · 2019Review
- Thalamocortical Circuit Motifs: A General Framework.Neuron · 2019Review
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7 authors at 2 institutions in 2 countries.
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Abstract
Rodents extract information about nearby objects from the movement of their whiskers through dynamic computations that are carried out by a network of forebrain structures that includes the thalamus and the primary sensory (S1BF) and motor (M1wk) whisker cortices. The posterior nucleus (Po), a higher order thalamic nucleus, is a key hub of this network, receiving cortical and brainstem sensory inputs and innervating both motor and sensory whisker-related cortical areas. In a recent study in rats, we showed that Po inputs differently impact sensory processing in S1BF and M1wk. Here, in C57BL/6 mice, we measured Po synaptic bouton layer distribution and size, compared cortical unit response latencies to "in vivo" Po activation, and pharmacologically examined the glutamatergic receptor mechanisms involved. We found that, in S1BF, a large majority (56%) of Po axon varicosities are located in layer (L)5a and only 12% in L2-L4, whereas in M1wk this proportion is inverted to 18% and 55%, respectively. Light and electron microscopic measurements showed that Po synaptic boutons in M1wk layers 3-4 are significantly larger (~ 50%) than those in S1BF L5a. Electrical Po stimulation elicits different area-specific response patterns. In S1BF, responses show weak or no facilitation, and involve both ionotropic and metabotropic glutamate receptors, whereas in M1wk, unit responses exhibit facilitation to repetitive stimulation and involve ionotropic NMDA glutamate receptors. Because of the different laminar distribution of axon terminals, synaptic bouton size and receptor mechanisms, the impact of Po signals on M1wk and S1BF, although simultaneous, is likely to be markedly different.
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