ArticleJournal of diabetes and metabolic disorders2018
Endothelin-1 traps potently reduce pathologic markers back to basal levels in an in vitro model of diabetes.
Article in Journal of diabetes and metabolic disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications.Advanced drug delivery reviews · 2024Review
- Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders.World journal of diabetes · 2022Article
- Review
- Correlation between MTHFR gene polymorphism and homocysteine levels for prognosis in patients with pregnancy-induced hypertension.American journal of translational research · 2021Article
- In vivo studies demonstrate that endothelin-1 traps are a potential therapy for type I diabetes.Journal of diabetes and metabolic disorders · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
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Abstract
backgroundDiabetes mellitus is a group of metabolic disorders in which there are high blood glucose levels over a prolonged period. Diabetes is one of many diseases associated with pathologically elevated levels of endothelin (ET)-1. We have recently proposed the development of ET-traps, which are an antibody - based fusion protein that potently bind and sequester pathologically elevated levels of endothelin-1.
methodsWe constructed ET-traps that were found to be very potent binders to ET-1, with a K
resultsIn this study, we investigated the effects of our ET-trap constructs on the expression levels of both collagen 4α1 and fibronectin, which are both important pathologic markers in diabetes. Treating HRMECs with 10 nM ET-1 or 25 mM glucose significantly induces the expression of the ECM proteins fibronectin and collagen 4α1, as is found in chronic diabetic complications; Incubation of the cells with the ET-traps significantly prevented the increased expression of fibronectin and collagen 4α1 back to basal levels. This was found with both mRNA and protein expression levels of the two ECM proteins.
conclusionOur results provide the first evidence of the efficacy of ET-traps in reducing pathologic markers in an in vitro model (of diabetes). Further research is warranted to determine the efficacy of ET-traps as a therapeutic tool for diabetes, which is a major public health burden around the world.
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