ArticleJournal of biological engineering2019
Rational protein design of
Article in Journal of biological engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Recent Progress in Enzymatic Preparation of Chitooligosaccharides with a Single Degree of Polymerization and Their Potential Applications in the Food Sector.Applied biochemistry and biotechnology · 2024Review
- Heterogeneously deacetylated chitosans possess an unexpected regular pattern favoring acetylation at every third position.Nature communications · 2024Article
- Fast insights into chitosan-cleaving enzymes by simultaneous analysis of polymers and oligomers through size exclusion chromatography.Scientific reports · 2024Article
- Article
- Addressing the Selectivity of Enzyme Biosensors: Solutions and Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Preparation of Defined Chitosan Oligosaccharides Using Chitin Deacetylases.International journal of molecular sciences · 2020Review
- Enzymatic Modifications of Chitin, Chitosan, and Chitooligosaccharides.Frontiers in bioengineering and biotechnology · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPartially acetylated chito-oligosaccharides (paCOS) have a variety of potential applications in different fields, but to harness their benefits, pure paCOS or well-defined paCOS mixtures are essential. For example, if one could produce fully acetylated (A
resultsFor this purpose, we performed rational protein engineering on the extensively studied GH 8 chitosanase CSN from
conclusionThe value of protein engineering as a tool for the more efficient production of pure oligomers and potentially bioactive paCOS mixtures was demonstrated by the results and the suitability of specific muteins for the large-scale production of strictly defined, pure paCOS in a batch process was shown using the example of D
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.