Evidence map›Paper›PMID 30918508›Full record

ArticleFrontiers in immunology2019

Early Enzyme Replacement Therapy Improves Hearing and Immune Defects in Adenosine Deaminase Deficient-Mice.

Xiaobai Xu, Jaina Negandhi, Weixian Min, Michael Tsui, Martin Post, Robert V Harrison, Eyal Grunebaum

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Purinergic Signalling in the Cochlea.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Article
  7. Ultrasonic bone removal from the ossicular chain affects cochlear structure and function.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2021
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiaobai XuInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Jaina NegandhiNeuroscience and Mental Health Program, Hospital for Sick Children, Toronto, ON, Canada.
Weixian MinDevelopmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
Michael TsuiInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Martin PostTranslational Medicine Program, Hospital for Sick Children, Toronto, ON, Canada.
Robert V HarrisonInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Eyal GrunebaumInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Hospital for Sick Children · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adenosine DeaminaseAgammaglobulinemiaAnimalsEnzyme Replacement TherapyHair Cells, AuditoryHearing LossMiceMice, KnockoutSevere Combined ImmunodeficiencyAdenosine Deaminaseadenosine deaminase deficiencyenzyme replacementenzyme replacement therapyhearingPEG-ADA

Identifiers

PMID30918508
PMCPMC6424861
OpenAlexW2916710245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.