Evidence map›Paper›PMID 30918358›Full record

ArticleGenetics in medicine : official journal of the American College of Medical Genetics2019

The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.

Emma J Crosbie, Neil A J Ryan, Mark J Arends, Tjalling Bosse, John Burn, Joanna M Cornes, Robin Crawford, Diana Eccles, Ian M Frayling, Sadaf Ghaem-Maghami and 20 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Gender bias in shared decision-making among cancer care guidelines: A systematic review.Health expectations : an international journal of public participation in health care and health policy · 2023
    Pooled it
  6. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Guideline
  7. Validity of a two-antibody testing algorithm for mismatch repair deficiency testing in cancer; a systematic literature review and meta-analysis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Pooled it
  8. Pooled it
  9. Screening and risk reducing surgery for endometrial or ovarian cancers in Lynch syndrome: a systematic review.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2022
    Pooled it
  10. Guideline
  11. Pooled it
  12. Guideline
  13. ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.Virchows Archiv : an international journal of pathology · 2021
    Guideline
  14. The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
    Pooled it
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Emma J CrosbieDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK. Emma.crosbie@manchester.ac.uk.ORCID http://orcid.org/0000-0003-0284-8630
Neil A J RyanDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.
Mark J ArendsDivision of Pathology & Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Tjalling BossePathology Department, Leiden University Medical Center, Leiden, the Netherlands.
John BurnInstitute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Joanna M CornesPatient Representative, Cambridge, UK.
Robin CrawfordDepartment of Gynaecological Oncology, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Diana EcclesFaculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK.
Ian M FraylingInstitute of Cancer and Genetics, Cardiff University, Cardiff, UK.
Sadaf Ghaem-MaghamiDepartment of Surgery and Cancer, Imperial College, London, UK.
Heather HampelDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Noah D KauffDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.
Henry C KitchenerDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.
Sarah J KitsonDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.
Ranjit ManchandaBarts Cancer Institute, Queen Mary University of London, London, UK.
Raymond F T McMahonDepartment of Histopathology, Manchester University NHS Foundation Trust, Manchester, UK.
Kevin J MonahanChelsea & Westminster Hospital NHS Trust, London, UK.
Usha MenonMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, London, UK.
Pål MøllerDepartment of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Oslo, Norway.
Gabriela MösleinCenter for Hereditary Tumors, Helios University Hospital Wuppertal, University of Witten-, Herdecke, Germany.
Adam RosenthalDepartment of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK.
Peter SasieniSchool of Cancer and Pharmaceutical Sciences, Kings College London, London, UK.
Mourad W SeifDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.
Naveena SinghDepartment of Cellular Pathology, Barts Health NHS Trust, London, UK.
Pauline SkarrottLynch Syndrome UK, Linden House, 9/11 Main Street, Ingleton, Carnforth, UK.
Tristan M SnowsillPeninsula Technology Assessment Group (PenTAG), University of Exeter, Exeter, UK.
Robert SteeleDivision of Cancer, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK.
Marc TischkowitzAcademic Laboratory of Medical Genetics, University of Cambridge, Cambridge, UK.
Manchester International Consensus Group
D Gareth EvansPrevention Early Detection Theme, NIHR Biomedical Research Centre, The Christie NHS Foundation Trust, Manchester, UK.ORCID http://orcid.org/0000-0002-8482-5784

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Cancer Research UK 16892Cancer Research UK 27047Cancer Research UK 27963Department of Health IS-BRC-1215-20007Department of Health NF-SI- 0513-10076Department of Health NIHR-CS-012-009Medical Research Council MR/M018431/1NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

purposeThere are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.

methodsStakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.

resultsGuidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.

conclusionThis document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisEarly Detection of CancerEndometrial NeoplasmsEuropeFemaleGenital Neoplasms, FemaleHumansMass ScreeningNorth AmericaOvarian Neoplasmsendometrial cancerguidanceLynch syndromescreeningsurveillance

Identifiers

PMID30918358
PMCPMC6774998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.