Evidence map›Paper›PMID 30918342›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

A multi-center evaluation of a device for measurement of bilirubin binding capacity in neonates: the effects of gestational age, Intralipid exposure and illness severity.

David L Schutzman, Vinod K Bhutani, Martin E Castillo Cuadrado, Angelo A Lamola, Ivan Frantz, Evelyn Obregon, Ronald J Wong

Abstract readEvaluation StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David L SchutzmanDepartment of Pediatrics, Einstein Medical Center Philadelphia, Philadelphia, PA, USA. SchutzmanD@einstein.edu.
Vinod K BhutaniDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0770-6543
Martin E Castillo CuadradoDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Angelo A LamolaDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Ivan FrantzDepartment of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2200-4286
Evelyn ObregonDepartment of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2543-1141
Ronald J WongDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1205-6936

Funding

Bilirubin Binding Capacity To Assess Bilirubin Load in Preterm InfantsR21HD082319 · NICHD · STANFORD UNIVERSITY · PI BHUTANI, VINOD K · 2016 to 2017
$454k
NICHD NIH HHS R21 HD082319
6 · The paper itself

Abstract

objectiveMeasure daily bilirubin-binding capacity (BBC) variation using an automated, not as-yet FDA approved, Point-of-Care hematofluorometer. Measure the effects of prematurity, clinical instability and exposure to Intralipid on BBC. SUBJECTS: Convenience sample of 109 infants from well-baby and intensive care nurseries. Gestational ages 28-41 weeks. 261 specimens obtained from postnatal ages 1-4 days. Unstable neonates were defined by need for at least noninvasive respiratory support and FiO2 ≥ 0.25.

resultsMedian interday variation was 2.9 ± 5.1 mg/dL. BBC (0.254 mg/dL/wk) and albumin (0.037 g/dL/wk) increased for each week of gestation. BBC was lower in unstable compared to well infants (26.1 ± 7.6 mg/dL v 28.6 ± 6.3 mg/dL). BBC was not significantly different in infants receiving or not receiving IL.

conclusionsBBC measurements using the device had acceptable intraspecimen reproducibility and interday variability. BBC may be helpful in guiding the assessment of aggressive versus conservative management decisions in preterm and sick infants with hyperbilirubinemia.

Indexed as

BilirubinFemaleGestational AgeHumansHyperbilirubinemiaInfantInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalPoint-of-Care SystemsPredictive Value of TestsReproducibility of ResultsSerum AlbuminSpectrometry, FluorescenceBilirubinSerum Albumin

Identifiers

PMID30918342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.