ArticleScientific reports2019
Renal size and cardiovascular risk in prepubertal children.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- The correlation of perirenal fat and atherosclerosis: A systematic review and meta-analysis.Science progressPooled it
- Effect of Protein Intake Early in Life on Kidney Volume and Blood Pressure at 11 Years of Age.Nutrients · 2023Trial
- Early signs of nephropathy in adolescents with obesity.International journal of obesity (2005) · 2026Article
- Body surface area-based kidney length percentiles misdiagnose small kidneys in children with overweight/obesity.Pediatric nephrology (Berlin, Germany) · 2023Article
- Ultrasound Renal Score to Predict the Renal Disease Prognosis in Patients with Diabetic Kidney Disease: An Investigative Study.Diagnostics (Basel, Switzerland) · 2023Article
- Reference Ranges of Age-Based Liver, Spleen, Pancreas, and Kidney Size in Conjunction with Waist Circumference in Children.Turkish archives of pediatrics · 2022Article
- Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.Clinical and translational science · 2021Article
- Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children.Scientific reports · 2021Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal size is an important parameter for the evaluation and diagnosis of kidney disease and has been associated with several cardiovascular risk factors in patients with kidney failure. These results are however discordant and studies in healthy children are lacking. We aimed to study the association between renal size (length and volume) and cardiovascular risk parameters in healthy children. Clinical, analytical and ultrasound parameters [renal length, renal volume, perirenal fat and carotid intima-media thickness (cIMT)] were determined in 515 healthy prepubertal children (176 lean, 208 overweight and 131 obese). Renal length and volume associated significantly and positively with several anthropometric and cardiovascular risk parameters including cIMT and systolic blood pressure (SBP) (all p < 0.001). Renal length and volume associated with cIMT and SBP in all study subgroups, but these associations were predominant in obese children, in whom these associations were independent after adjusting for age, gender and BSA (all p < 0.05). In multivariate analyses in the study subjects as a whole, renal length was an independent predictor of cIMT (β = 0.310, p < 0.0001) and SBP (β = 0.116, p = 0.03). Renal size associates with cIMT and SBP, independent of other well-established cardiovascular risk factors, and may represent helpful parameters for the early assessment of cardiovascular risk in children.
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