ArticleNutrition & diabetes2019
Fat redistribution and accumulation of visceral adipose tissue predicts type 2 diabetes risk in middle-aged black South African women: a 13-year longitudinal study.
Article in Nutrition & diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Whether or Not the Effects ofNutrients · 2020Pooled it
- Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function.Scientific reports · 2020Trial
- A Pilot Study to Describe Cardiometabolic Health Indicators and Prescription Medication Use in Postmenopausal Women with a Self-Reported History of PMOS.Journal of clinical medicine · 2026Article
- Machine learning-based estimation of trunk fat percentage and its association with cardiometabolic risk leveraging two large national cohorts.Frontiers in nutrition · 2026Article
- Maternal Anthropometry, Body Composition, and Fat Distribution by HIV Status and Antiretroviral Therapy Class in South African Women.AIDS research and human retroviruses · 2025Article
- Association between body composition measured using Dual-Energy X-Ray absorptiometry and incident type 2 diabetes mellitus in adults: A systematic review.Journal of diabetes and metabolic disorders · 2025Review
- Fat talks first: how adipose tissue sets the pace of aging?Life medicine · 2025Review
- Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B.Scientific reports · 2025Article
- White adipose tissue in type 2 diabetes and the effect of antidiabetic drugs.Diabetology & metabolic syndrome · 2025Review
- Postprandial glucose variability and clusters of sex hormones, liver enzymes, and cardiometabolic factors in a South African cohort of African ancestry.BMJ open diabetes research & care · 2024Article
- Biomarkers of aging.Science China. Life sciences · 2023Review
- Pathophysiology of type 2 diabetes in sub-Saharan Africans.Diabetologia · 2022Review
- Waist circumference thresholds predicting incident dysglycaemia and type 2 diabetes in Black African men and women.Diabetes, obesity & metabolism · 2022Article
- Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women.European journal of endocrinology · 2022Article
- Article
- Adipocyte Heterogeneity Underlying Adipose Tissue Functions.Endocrinology · 2022Review
- Assessing visceral and subcutaneous adiposity using segmented T2-MRI and multi-frequency segmental bioelectrical impedance: A sex-based comparative study.Acta bio-medica : Atenei Parmensis · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCross-sectional studies in South Africa (SA) have shown that black SA women, despite being more insulin resistant, have less visceral adipose tissue (VAT) and more subcutaneous adipose tissue (SAT) than white women. This study aimed to investigate whether baseline and/or change in body fat and its distribution predict type 2 diabetes (T2D) risk in middle-aged black SA women, 13 years later.
methodsWe studied 142 black SA women who are the caregivers of the Birth-to-Twenty plus cohort, and who had normal glucose tolerance (NGT) at baseline. At baseline and follow-up, fasting blood samples, basic anthropometry and dual-energy X-ray absorptiometry-derived body composition were measured. At follow-up, an oral glucose tolerance test was completed. The WHO diabetes diagnostic criteria were used to define NGT, impaired fasting glucose (IFG)/impaired glucose tolerance (IGT), impaired glucose metabolism (IGM) and T2D.
resultsAt follow-up, 64% of participants remained NGT, whereas 25% developed IGM, and 11% developed T2D. The IGM and the T2D groups were combined for statistical analyses. At baseline, trunk fat mass (FM), VAT but not SAT (measures of central FM) were higher in the IGM/T2D group than the NGT group (p < 0.0001). In contrast, the IGM/T2D group had lower leg %FM at baseline than the NGT group (p < 0.0001). Baseline trunk FM (Odds ratio per 1 kg increase (95% confidence interval, 1.95 (1.43-2.67))), and VAT (OR per 10 cm
conclusionsRelative fat redistribution, with VAT accumulation, predicted the development of IGM/T2D 13 years before its onset. Prevention of central obesity is a key factor to reduce the risk of developing T2D among middle-aged urban black SA women.
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