Evidence map›Paper›PMID 30918174›Full record

ArticleInternal medicine (Tokyo, Japan)2019

IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes.

Akira Okada, Takaaki Higashihara, Taiko Kusano, Koji Takemura, Hanako Saigusa, Sayako Maruno, Mimiko Matsumura, Takeo Suzuki, Akira Shimizu, Hideki Takano

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Akira OkadaDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Japan.
Takaaki HigashiharaDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Japan.
Taiko KusanoDepartment of Nephrology, Tokyo Teishin Hospital, Japan.
Koji TakemuraDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Japan.
Hanako SaigusaDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Japan.
Sayako MarunoDepartment of Nephrology, Tokyo Teishin Hospital, Japan.
Mimiko MatsumuraDepartment of Nephrology, Tokyo Teishin Hospital, Japan.
Takeo SuzukiDepartment of Interventional Radiology, Tokyo Teishin Hospital, Japan.
Akira ShimizuDepartment of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Japan.
Hideki TakanoDepartment of Nephrology, Tokyo Teishin Hospital, Japan.
Tokyo Teishin Hospital · JPThe University of Tokyo · JPNippon Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 83-year-old man with stable chronic kidney disease (CKD) exhibited a sudden increase in urinary N-acetyl-β-D-glucosaminidase and protein excretion, suggesting aggravated kidney damage. Simultaneously, he lost diabetic control, requiring up to 54 units of insulin daily. A detailed examination revealed the presence of renal cell carcinoma, which was surgically resected and confirmed to be interleukin-6-positive by immunohistochemistry. Postoperatively, his uni-nephrectomy necessitated hemodialysis, but the patient's insulin resistance was ameliorated; no medication was required to control diabetes, suggesting that the tumor had caused the insulin resistance. This report describes a case of a tumor secreting interleukin-6, which affects both the control of diabetes and CKD progression.

Indexed as

Aged, 80 and overCarcinoma, Renal CellDisease ProgressionHexosaminidasesHumansInterleukin-6Kidney NeoplasmsMaleNephrectomyParaneoplastic Endocrine SyndromesRenal Insufficiency, ChronicTreatment OutcomeHexosaminidasesInterleukin-6chronic kidney disease (CKD)diabetes mellitusinsulin resistanceinterleukin-6 (IL-6)paraneoplastic syndromerenal cell carcinoma

Identifiers

PMID30918174
PMCPMC6663549
OpenAlexW2923763273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.