Evidence map›Paper›PMID 30918072›Full record

ArticleJournal of virology2019

Modeling HIV-1 Latency Using Primary CD4

Hiroshi Takata, Cari Kessing, Aaron Sy, Noemia Lima, Julia Sciumbata, Luisa Mori, R Brad Jones, Nicolas Chomont, Nelson L Michael, Susana Valente and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. How CD4Biomedicines · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Hiroshi TakataHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.ORCID 0000-0003-1457-6919
Cari KessingThe Scripps Research Institute, Jupiter, Florida, USA.
Aaron SyHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Noemia LimaHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Julia SciumbataHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Luisa MoriThe Scripps Research Institute, Jupiter, Florida, USA.
R Brad JonesWeill Cornell Medical College, New York, New York, USA.
Nicolas ChomontCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Canada.
Nelson L MichaelHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Susana ValenteThe Scripps Research Institute, Jupiter, Florida, USA.
Lydie TrautmannHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA ltrautmann@hivresearch.org.ORCID 0000-0002-3012-0009
Henry M. Jackson Foundation · USScripps Research Institute · USCentre Hospitalier de l’Université de Montréal · CACornell University · US

Funding

BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1M
Mode of action of a new Tat HIV-1 inhibitorR01AI097012 · NIAID · UNIVERSITY OF FLORIDA · PI VALENTE, SUSANA T · 2012 to 2022
$7.5M
Towards HIV eradication using a novel Tat inhibitorR01AI118432 · NIAID · SCRIPPS FLORIDA · PI VALENTE, SUSANA T · 2015 to 2019
$2.3M
NIAID NIH HHS R01 AI097012NIAID NIH HHS R01 AI118432NIAID NIH HHS UM1 AI126617
6 · The paper itself

Abstract

The low frequency of latently HIV-infected cells

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV InfectionsHIV SeropositivityHumansModels, BiologicalPrimary Cell CultureProvirusesVirus ActivationVirus LatencyVirus Replicationhuman immunodeficiency viruslatency modelprimary CD4 T cells

Identifiers

PMID30918072
PMCPMC6532074
OpenAlexW2924717068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.