Evidence map›Paper›PMID 30918062›Full record

ArticlemSphere2019

Extracellular Vesicle-Mediated RNA Release in

Lysangela R Alves, Roberta Peres da Silva, David A Sanchez, Daniel Zamith-Miranda, Marcio L Rodrigues, Samuel Goldenberg, Rosana Puccia, Joshua D Nosanchuk

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Selective DNA encapsulation in extracellular vesicles ofExtracellular vesicles and circulating nucleic acids · 2026
    Article
  3. Review
  4. Review
  5. Traversing the Cell Wall: The Chitinolytic Activity ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Caspofungin Affects Extracellular Vesicle Production and Cargo inJournal of fungi (Basel, Switzerland) · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Toward an Understanding of Extracellular tRNA Biology.Frontiers in molecular biosciences · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Lysangela R AlvesInstituto Carlos Chagas, Fiocruz, Curitiba, Cidade Industrial de Curitiba, Brazil lys.alves@gmail.com josh.nosanchuk@einstein.yu.edu.ORCID 0000-0002-1972-2658
Roberta Peres da SilvaDepartamento de Microbiologia, Imunologia e Parasitologia da Escola Paulista de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, Brazil.
David A SanchezDepartments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Daniel Zamith-MirandaDepartments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Marcio L RodriguesInstituto Carlos Chagas, Fiocruz, Curitiba, Cidade Industrial de Curitiba, Brazil.ORCID 0000-0002-6081-3439
Samuel GoldenbergInstituto Carlos Chagas, Fiocruz, Curitiba, Cidade Industrial de Curitiba, Brazil.
Rosana PucciaDepartamento de Microbiologia, Imunologia e Parasitologia da Escola Paulista de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo, Brazil.
Joshua D NosanchukDepartments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA lys.alves@gmail.com josh.nosanchuk@einstein.yu.edu.
Albert Einstein College of Medicine · USFundação Carlos Chagas · BRUniversidade Federal de São Paulo · BRUniversidade Federal do Rio de Janeiro · BR

Funding

Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
Antibody differentially alters Histoplasma extracellular vesiclesR21AI124797 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI NOSANCHUK, JOSHUA D · 2016 to 2017
$538k
NIAID NIH HHS R01 AI052733NIAID NIH HHS R21 AI124797
6 · The paper itself

Abstract

Eukaryotic cells, including fungi, release extracellular vesicles (EVs). These lipid bilayered compartments play essential roles in cellular communication and pathogenesis. EV composition is complex and includes proteins, glycans, pigments, and RNA. RNAs with putative roles in pathogenesis have been described in EVs produced by fungi. Here we describe the RNA content in EVs produced by the G186AR and G217B strains of

Indexed as

Extracellular VesiclesFungal ProteinsGene Expression ProfilingGene Expression Regulation, FungalHigh-Throughput Nucleotide SequencingHistoplasmaMicroRNAsRNA, FungalRNA, MessengerStress, PhysiologicalFungal ProteinsMicroRNAsRNA, FungalRNA, Messengerextracellular vesiclesHistoplasma capsulatumRNA

Identifiers

PMID30918062
PMCPMC6437275
OpenAlexW2950094403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.