Evidence map›Paper›PMID 30918060›Full record

ArticlemSphere2019

Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis.

Ruwen Yang, Jana Klimentová, Elke Göckel-Krzikalla, Regina Ly, Nadine Gmelin, Agnes Hotz-Wagenblatt, Helena Řehulková, Jiří Stulík, Frank Rösl, Martina Niebler

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ruwen YangDivision of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jana KlimentováDepartment of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic.
Elke Göckel-KrzikallaDivision of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Regina LyDivision of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nadine GmelinDivision of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Agnes Hotz-WagenblattCore Facility Omics IT and Data Management (ODCF), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Helena ŘehulkováDepartment of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic.
Jiří StulíkDepartment of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic.
Frank Rösl *Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany f.roesl@dkfz-heidelberg.de m.niebler@dkfz-heidelberg.de.
Martina Niebler *Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany f.roesl@dkfz-heidelberg.de m.niebler@dkfz-heidelberg.de.
German Cancer Research Center · DEHeidelberg University · DEUniversity of Defence · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in cancer development has been intensively studied during the last decades, there is still the necessity of understanding the impact of the HPV

Indexed as

Gene Regulatory NetworksTranscriptomeAdenocarcinomaCarcinogenesisCarcinoma, Squamous CellCell Transformation, NeoplasticComputational BiologyFemaleGene Expression ProfilingHigh-Throughput Nucleotide SequencingHuman papillomavirus 16HumansKeratinocytesOncogene Proteins, ViralProteomeProteomicsOncogene Proteins, ViralProteomecervical cancerhead and neck cancerHPVintegrated analysisRNA-SeqSILACTCGA

Identifiers

PMID30918060
PMCPMC6437273
OpenAlexW2923782673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.