ArticleDrug metabolism and disposition: the biological fate of chemicals2019
Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity.
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Article in Drug metabolism and disposition: the biological fate of chemicals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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7 citing papers in PubMed, 17 citations in OpenAlex.
- The Role of CYP3A in Health and Disease.Biomedicines · 2022Review
- Article
- Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform.Frontiers in pharmacology · 2022Article
- Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7.International journal of molecular sciences · 2021Article
- The 1β-Hydroxy-Deoxycholic Acid to Deoxycholic Acid Urinary Metabolic Ratio: Toward a Phenotyping of CYP3A Using an Endogenous Marker?Journal of personalized medicine · 2021Article
- Domain-Swap Dimerization ofMolecular pharmacology · 2020Article
- Species Differences of Bile Acid Redox Metabolism: Tertiary Oxidation of Deoxycholate is Conserved in Preclinical Animals.Drug metabolism and disposition: the biological fate of chemicals · 2020Article
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Authors and funding
14 authors at 1 institution in 2 countries.
Yu-Jie ChenKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Jian ZhangKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Ping-Ping ZhuKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Xian-Wen TanKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Qiu-Hong LinKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Wen-Xia WangKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Shan-Shan YinKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Ling-Zhi GaoKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Ming-Ming SuKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Chang-Xiao LiuKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Liang XuKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Wei JiaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.).
Irina F SevrioukovaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.) sevrioui@uci.edu.
Ke LanKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.) lanwoco@scu.edu.cn.ORCID 0000-0002-9237-9219
University of Hawaiʻi at Mānoa · US
Funding
Toxicological importance of CYP3A4 catalysis and inhibitionR01ES025767 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEVRIOUKOVA, IRINA F · 2016 to 2025
$4.0MNIEHS NIH HHS R01 ES025767
Abstract
The primary bile acids (BAs) synthesized from cholesterol in the liver are converted to secondary BAs by gut microbiota. It was recently disclosed that the major secondary BA, deoxycholate (DCA) species, is stereoselectively oxidized to tertiary BAs exclusively by CYP3A enzymes. This work subsequently investigated the in vitro oxidation kinetics of DCA at C-1
Indexed as
BiomarkersCytochrome P-450 CYP3ADeoxycholic AcidHumansHydroxylationKineticsLiverMicrosomes, LiverOxidation-ReductionBiomarkersCYP3A7 protein, humanCytochrome P-450 CYP3ADeoxycholic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.