Evidence map›Paper›PMID 30917856›Full record

SynthesisCritical care (London, England)2019

The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis.

Yue-Nan Ni, Guo Chen, Jiankui Sun, Bin-Miao Liang, Zong-An Liang

Erratum issuedOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 224 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed, 15 pooled it
51.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

224 citing papers in PubMed, 15 syntheses or guidelines pooled it, 401 citations in OpenAlex.

  1. Pooled it
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  5. Steroid therapy and antiviral treatment in SARS-CoV-2 pneumonia: clinical contexts and indications.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Pooled it
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  8. Immunomodulation as Treatment for Severe Coronavirus Disease 2019: A Systematic Review of Current Modalities and Future Directions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Pooled it
  9. Guideline
  10. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020
    Pooled it
  11. Guideline
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  16. Trial
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164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yue-Nan NiDepartment of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Guo ChenDepartment of Geriatrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Jiankui SunState Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No. 14, Section 3 Renmin Nanlu, Chengdu, 610041, Sichuan, China.
Bin-Miao LiangDepartment of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China. liangbinmiao@163.com.
Zong-An LiangDepartment of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Sichuan University · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

Department of Science and Technology of Sichuan Province 2019YFS0033Ministry of Science and Technology of the People's Republic of China 2013BAI09B09the national key research and development program of China 2016YFC1304303
6 · The paper itself

Abstract

backgroundThe effect of corticosteroids on clinical outcomes in patients with influenza pneumonia remains controversial. We aimed to further evaluate the influence of corticosteroids on mortality in adult patients with influenza pneumonia by comparing corticosteroid-treated and placebo-treated patients.

methodsThe PubMed, Embase, Medline, Cochrane Central Register of Controlled Trials (CENTRAL), and Information Sciences Institute (ISI) Web of Science databases were searched for all controlled studies that compared the effects of corticosteroids and placebo in adult patients with influenza pneumonia. The primary outcome was mortality, and the secondary outcomes were mechanical ventilation (MV) days, length of stay in the intensive care unit (ICU LOS), and the rate of secondary infection.

resultsTen trials involving 6548 patients were pooled in our final analysis. Significant heterogeneity was found in all outcome measures except for ICU LOS (I

conclusionsIn patients with influenza pneumonia, corticosteroid use is associated with higher mortality.

trial registrationPROSPERO (ID: CRD42018112384 ).

Indexed as

Adrenal Cortex HormonesHumansInfluenza, HumanLength of StayPneumoniaRespiration, ArtificialStatistics, NonparametricAdrenal Cortex HormonesCorticosteroidsInfluenza pneumoniaMortality

Identifiers

PMID30917856
PMCPMC6437920
OpenAlexW2927678279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.