ArticleBMC infectious diseases2019
Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Cardiac injury in children with severe hand, foot and mouth disease: risk factors and clinical outcomes.Infection · 2026Article
- Highly sensitive and rapid determination of Coxsackievirus A16 using restriction endonuclease-mediated reverse transcription multiple cross displacement amplification.BMC microbiology · 2026Article
- Clinical efficacy and mechanistic insights of Xuebijing in hand, foot, and mouth disease: a meta-analysis with integrated pharmacological approaches.Annals of medicine and surgery (2012) · 2025Review
- Insights into the mechanisms of apoptosis and pathogenesis in enterovirus 71 infections: A review.Medicine · 2025Review
- Characteristics of CVA16 B1c strains isolated for the first time in the Heilongjiang Province of China.Frontiers in microbiology · 2025Article
- Efficient Production of Enterovirus 71 (EV71) Virus-like Particles by Controlling Promoter Strength in Insect Cells.Viruses · 2024Article
- Seasonal Testing, Results, and Effect of the Pandemic on Coxsackievirus Serum Studies.Microorganisms · 2024Article
- Study of the influence of meteorological factors on HFMD and prediction based on the LSTM algorithm in Fuzhou, China.BMC infectious diseases · 2023Article
- Current status of hand-foot-and-mouth disease.Journal of biomedical science · 2023Review
- Impact of meteorological factors on the incidence of hand-foot-mouth disease in Yangzhou from 2017 to 2022: a time series study.Frontiers in public health · 2023Article
- Drug Repositioning for Hand, Foot, and Mouth Disease.Viruses · 2022Review
- Hand, Foot, and Mouth Disease: A Narrative Review.Recent advances in inflammation & allergy drug discovery · 2022Review
- Analysis of miRNAs Involved in Mouse Heart Injury Upon Coxsackievirus A2 Infection.Frontiers in cellular and infection microbiology · 2022Article
- Epidemiology of hand, foot, and mouth disease and the genetic characteristics of Coxsackievirus A16 in Taiyuan, Shanxi, China from 2010 to 2021.Frontiers in cellular and infection microbiology · 2022Article
- Seroprevalence of coxsackievirus A16 antibody among people of various age groups: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2021Review
- Oral ulcers in children- a clinical narrative overview.Italian journal of pediatrics · 2021Review
- Regional-level risk factors for severe hand-foot-and-mouth disease: an ecological study from mainland China.Environmental health and preventive medicine · 2021Article
- Coxsackievirus A16 in Southern Vietnam.Frontiers in microbiology · 2021Article
- Molecular Epidemiology and Clinical Features of Enteroviruses-Associated Hand, Foot, and Mouth Disease and Herpangina Outbreak in Zunyi, China, 2019.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHand, foot and mouth disease (HFMD) is a transmissible infectious disease caused by human enteroviruses (EV). Here, we described features of children with severe HFMD caused by EV-A71 or coxsackievirus A16 (CV-A16) in Shanghai, China.
methodsSevere EV-A71 or CV-A16 caused HFMD children admitted to the Xinhua Hospital from January 2014 and December 2016, were recruited retrospectively to the study. Symptoms and findings at the time of hospitalization, laboratory tests, treatments, length of stay and residual findings at discharge were systematically recorded and analyzed.
resultsOf 19,995 children visited clinic service with probable HFMD, 574 children (2.87%) were admitted, 234 children (40.76%) were confirmed with EV-A71 (90/574) or CV-A16 (144/574) disease. Most (91.02%) of the patients were under 5 years. Initial clinical symptoms of EV-A71 and CV-A16 cases were: fever > 39 °C in 81 (90%) and 119 (82.63%), vomiting in 31 (34.44%) and 28 (19.44%), myoclonic twitching in 19 (21.11%) and 11(7.64%), startle in 21 (23.33%) and 20 (13.69%), respectively. Serum levels of interleukin-1β (IL-1β), IL-2, IL-6, IL-8, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) were significantly upregulated in severe HFMD subjects. Forty-seven children (20.08%) treated with intravenous gamma globulin (IVIG) showed decreased duration of illness episodes. All children were discharged without complications.
conclusionsEV-A71 and CV-A16 accounted 40.76% of admitted HFMD during 2014 to 2016 in Xinhua Hospital. IVIG appeared to be beneficial in shortening the duration of illness episodes of severe HFMD.
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