ArticleBMC infectious diseases2019
A cross-sectional study of enteric fever among febrile patients at Ambo hospital: prevalence, risk factors, comparison of Widal test and stool culture and antimicrobials susceptibility pattern of isolates.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Risk Factors for Typhoid Fever: Systematic Review.JMIR public health and surveillance · 2025Pooled it
- Prevalence, probability, and outcomes of typhoidal/non-typhoidal Salmonella and malaria co-infection among febrile patients: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Corrigendum to "Multidrug resistance from a one health perspective in Ethiopia: a systematic review and meta-analysis of literatures (2015-2020)" [One Health 14(2022) 1-12/100390].One health (Amsterdam, Netherlands) · 2025Article
- Colorimetric CRISPR Biosensor: A Case Study with Salmonella Typhi.ACS sensors · 2025Article
- Seroprevalence of Typhoid Fever and Its Associated Risk Factors Among Clinically Diagnosed Febrile Patients Visiting the Outpatient Department at Debark Hospital and Drug Susceptibility Patterns of Isolates.BioMed research international · 2025Article
- Malaria and Typhoid Fever Coinfection Among Febrile Patients Attending a Health Facility in Yaoundé, Cameroon: A Cross-Sectional Study.Journal of parasitology research · 2025Article
- Prevalence of Salmonella Typhi, its associated factors and antimicrobial susceptibility profile among patients attending Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia.BMC infectious diseases · 2024Article
- Incidence of typhoid fever in Burkina Faso, Democratic Republic of the Congo, Ethiopia, Ghana, Madagascar, and Nigeria (the Severe Typhoid in Africa programme): a population-based study.The Lancet. Global health · 2024Article
- Health facility-based prevalence of typhoid fever, typhus and malaria among individuals suspected of acute febrile illnesses in Southwest Region, Ethiopia.Frontiers in epidemiology · 2024Article
- Epidemiology of Multidrug-ResistantJournal of tropical medicine · 2024Article
- Coinfection of Malaria and Bacterial Pathogens among Acute Febrile Patients in Selected Clinics in Ghana.The American journal of tropical medicine and hygiene · 2023Article
- Rapid stool antigenic test for typhoid fever among suspected cases, Northeast, Ethiopia.Scientific reports · 2023Article
- Co-existence of extended-spectrum β-lactamases blaEuropean journal of medical research · 2023Article
- Prevalence and antimicrobial susceptibility level of typhoid fever in Ethiopia: A systematic review and meta-analysis.Preventive medicine reports · 2022Article
- Management of febrile illness in rural Guinea over a seven-year period: A retrospective study.PLOS global public health · 2022Article
- Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern Ethiopia.Journal of tropical medicine · 2022Article
- Risk factors for some tropical diseases in an African country.BMC public health · 2021Observational
- Clinicoepidemiological Observations of Enteric Fever in Infants: Experiences From a Tertiary Care Pediatric Hospital in North India.The Journal of infectious diseases · 2021Article
- Salmonella Typhi and Salmonella Paratyphi prevalence, antimicrobial susceptibility profile and factors associated with enteric fever infection in Bahir Dar, Ethiopia.Scientific reports · 2021Article
- Prevalence ofNew microbes and new infections · 2021Article
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2 authors at 1 institution in 1 country.
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Abstract
backgroundEnteric fever is one of the common infectious diseases of humans. The objectives of this study were to:1) estimate the prevalence of enteric fever among febrile patients visiting Ambo hospital; 2) comparison of Widal test and stool culture;3) evaluation of the antimicrobial susceptibility of isolates; and 4) assess potential risk factors to acquire enteric fever infection.
methodsBlood and stool samples were collected from 372 febrile patients with symptoms clinically similar to enteric fever. Widal test was used for testing sera while stool culturing and bacterial identification was done using WHO standard methods. Susceptibility testing was done using Kirby-Bauer disc diffusion method. Chi-Square test and Logistic Regression analysis were used to analyze the data.
resultsThe apparent and true prevalence of enteric fever were 56.2% (95% confidence interval [CI]: 50.97-61.29%) and 57.52% (95% CI: 52.3-62.6%) respectively, while, the culture prevalence was 2.7% (95% CI: 1.30-4.89%). Isolation rates of S. Typhi and S. Paratyphi were 0.8% (95% CI: 0.17-2.34%) and 1.9% (95% CI: 0.76-3.84%) respectively. The isolates showed 100% resistance to amoxicillin, bacitracin, erythromycin, 80%resistance to cefotaxime and streptomycin and 20% for chloramphenicol. The sensitivity, specificity, positive and negative predictive values of Widal test was 80.0, 44.5, 3.8 and 98.8% respectively. Multivariable logistic regression analysis revealed that age (adjusted odds ratio [aOR] = 2.45; 95% CI: 1.38-4.37; P = 0.002), religion (aOR = 15.57, 95% CI: 3.01-80.64; P = 0.001), level of education (aOR = 2.60, 95% CI: 1.27-5.28; P = 0.009), source of water (aOR = 2.20, 95% CI: 1.21-3.98; P = 0.009), raw milk (aOR =2.19, 95% CI:1.16-4.16; P = 0.016) and raw meat consumption (aOR = 1.80, 95% CI: 1.07-3.01; P = 0.026) are the predictors of enteric fever seropositivity.
conclusionsPatients were wrongly diagnosed and treated for enteric fever by Widal test. Therefore, rapid tests with better sensitivity and specificity are needed for the diagnosis of enteric fever. Provision of safe water and health education are vital to bring behavioral change towards raw food consumption.
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