Evidence map›Paper›PMID 30917621›Full record

ArticleMaterials (Basel, Switzerland)2019

Preparation, Characterization, and Stability Evaluation of Taste-Masking Lacosamide Microparticles.

Chang-Soo Han, Seungsu Kim, Dong-Won Oh, Jeong Yeol Yoon, Eun-Seok Park, Yun-Seok Rhee, Ju-Young Kim, Dae Hwan Shin, Dong-Wook Kim, Chun-Woong Park

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chang-Soo HanCollege of Pharmacy, Chungbuk National University, Cheongju 28160, Korea. hsoo0805@naver.com.ORCID 0000-0002-5431-9098
Seungsu KimCollege of Pharmacy, Chungbuk National University, Cheongju 28160, Korea. seungsu.kim@sandoz.com.
Dong-Won OhCollege of Pharmacy, Chungbuk National University, Cheongju 28160, Korea. odw0531@gmail.com.
Jeong Yeol YoonCollege of Pharmacy, Chungbuk National University, Cheongju 28160, Korea. ilyj777@naver.com.
Eun-Seok ParkSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea. espark@skku.edu.
Yun-Seok RheeCollege of Pharmacy, Research Institute of Pharmaceutical sciences, Gyeongsang National University, Jinju 52828, Korea. ysrhee@gnu.ac.kr.
Ju-Young KimCollege of Pharmacy, Woosuk University, Wanju-gun 55338, Korea. jykim@woosuk.ac.kr.
Dae Hwan ShinCollege of Pharmacy, Chungbuk National University, Cheongju 28160, Korea. dshin@chungbuk.ac.kr.
Dong-Wook KimDepartment of Pharmaceutical Engineering, Cheongju University, Cheongju 28530, Korea. pharmengin@gmail.com.
Chun-Woong ParkCollege of Pharmacy, Chungbuk National University, Cheongju 28160, Korea. cwpark@cbnu.ac.kr.ORCID 0000-0001-5329-8443

Funding

National Research Foundation of Korea NRF-2017R1A5A2015541National Research Foundation of Korea NRF- 2018R1A1A1A05023012National Research Foundation of Korea NRF-2018R1D1A1B07050538
6 · The paper itself

Abstract

Lacosamide (LCM) is a third-generation antiepileptic drug. Selective action of the drug on voltage-gated sodium channels reduces side effects. Oral administration of LCM shows good pharmacokinetic profile. However, the bitter taste of LCM is a barrier to the development of oral formulations. In this study, we aimed to prepare encapsulated LCM microparticles (MPs) for masking its bitter taste. Encapsulated LCM MPs were prepared with Eudragit

Indexed as

encapsulationpH dependentrecrystallizationsurface enrichmenttaste-masking effectiveness

Identifiers

PMID30917621
PMCPMC6470747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.