ArticleCell reports2019
Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- The role of microbiota derived metabolites in modulating diabetic inflammation: a systematic review.Journal of molecular histology · 2026Pooled it
- DuodenalGut · 2022Trial
- Trial
- Synergy between Enterobacteriaceae and diet mediates competition between dominant Bacteroidales in the human gut.Nature microbiology · 2026Article
- Divergent amino acid profiles in sarcopenic obesity versus non-obese sarcopenia: A prospective cohort study in community-dwelling older adults.The journal of nutrition, health & aging · 2026Article
- Giant Panda Feces-DerivedVeterinary sciences · 2026Article
- Article
- Gut microbiota gate host exposure to cholinesterase inhibitors from dietary Solanums.bioRxiv : the preprint server for biology · 2025Article
- Integrating microbial GWAS and single-cell transcriptomics reveals associations between host cell populations and the gut microbiome.Nature microbiology · 2025Article
- Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors.iScience · 2025Article
- Function-based selection of synthetic communities enables mechanistic microbiome studies.The ISME journal · 2025Article
- Probing and manipulating the gut microbiome with chemistry and chemical tools.Gut microbiome (Cambridge, England) · 2025Review
- Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology.Cell host & microbe · 2024Article
- Improved mouse models of the small intestine microbiota using region-specific sampling from humans.bioRxiv : the preprint server for biology · 2024Article
- Diet-gut microbiome interaction and ferulic acid bioavailability: implications on neurodegenerative disorders.European journal of nutrition · 2024Review
- The human intestinal bacteriumMicrobiome research reports · 2024Article
- Causal inference on microbiome-metabolome relations in observational host-microbiome data via in silico in vivo association pattern analyses.Cell reports methods · 2023Article
- Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications.FEMS microbiology reviews · 2023Article
- Short-term changes in dietary fat levels and starch sources affect weight management, glucose and lipid metabolism, and gut microbiota in adult cats.Journal of animal science · 2023Article
- Sterility testing of germ-free mouse colonies.Frontiers in immunology · 2023Review
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
The gut microbiota can modulate human metabolism through interactions with macronutrients. However, microbiota-diet-host interactions are difficult to study because bacteria interact in complex food webs in concert with the host, and many of the bacteria are not yet characterized. To reduce the complexity, we colonize mice with a simplified intestinal microbiota (SIM) composed of ten sequenced strains isolated from the human gut with complementing pathways to metabolize dietary fibers. We feed the SIM mice one of three diets (chow [fiber rich], high-fat/high-sucrose, or zero-fat/high-sucrose diets [both low in fiber]) and investigate (1) how dietary fiber, saturated fat, and sucrose affect the abundance and transcriptome of the SIM community, (2) the effect of microbe-diet interactions on circulating metabolites, and (3) how microbiota-diet interactions affect host metabolism. Our SIM model can be used in future studies to help clarify how microbiota-diet interactions contribute to metabolic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.