Evidence map›Paper›PMID 30917292›Full record

ArticleRadiology2019

Moving toward Noninvasive, Focused Ultrasound Therapeutic Delivery of Drugs in the Brain: Prolonged Opening of Blood-Brain Barrier May Not Be Needed.

Alexander L Klibanov, Nathan J McDannold

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexander L KlibanovFrom the Cardiovascular Division and Robert M. Berne Cardiovascular Research Center, University of Virginia, UVA CVRC, MR4 RM3147, 409 Lane Rd, Charlottesville, VA 22908 (A.L.K.); and Department of Radiology, Brigham and Women's Hospital, Boston, Mass (N.J.M.).
Nathan J McDannoldFrom the Cardiovascular Division and Robert M. Berne Cardiovascular Research Center, University of Virginia, UVA CVRC, MR4 RM3147, 409 Lane Rd, Charlottesville, VA 22908 (A.L.K.); and Department of Radiology, Brigham and Women's Hospital, Boston, Mass (N.J.M.).
Brigham and Women's Hospital · US

Funding

Non-invasive targeted neuromodulation via focused ultrasound BBB permeabilizationR01MH116858 · NIMH · HARVARD MEDICAL SCHOOL · PI LIVINGSTONE, MARGARET S, MCDANNOLD, NATHAN J. · 2018 to 2021
$2.4M
Ultrasound-triggered red blood cell drug delivery with photoacoustic trackingR01EB023055 · NIBIB · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L · 2017 to 2020
$2.3M
Ultrasound Enhanced Low Dose Drug Delivery: Quantifying Uptake, Retention and BiodistributionR44HL139241 · NHLBI · SOUNDPIPE, LLC · PI KILROY, JOSEPH P. · 2017 to 2018
$2.0M
Toward an accuracy-efficiency balanced model for modeling high intensity focused ultrasoundR01EB025205 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI JING, YUN · 2018 to 2020
$955k
NHLBI NIH HHS R44 HL139241NIBIB NIH HHS R01 EB023055NIBIB NIH HHS R01 EB025205NIMH NIH HHS R01 MH116858
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Blood-Brain BarrierPharmaceutical PreparationsAnimalsBrainMiceUltrasonographyPharmaceutical Preparations

Identifiers

PMID30917292
PMCPMC6490053
OpenAlexW2922717602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.