Evidence map›Paper›PMID 30917004›Full record

ReviewAnnual review of biochemistry2019

The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination.

Weixing Zhao, Claudia Wiese, Youngho Kwon, Robert Hromas, Patrick Sung

Abstract readReview
In one paragraph

Review in Annual review of biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. The immunology of human breast cancer.Nature reviews. Immunology · 2026
    Review
  5. Review
  6. Mechanisms and disease relevance of DNA break repair pathway choice.Nature reviews. Molecular cell biology · 2026
    Review
  7. Article
  8. Reclassification ofCurrent oncology (Toronto, Ont.) · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Targeting IPNature communications · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weixing ZhaoDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Claudia WieseDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.
Youngho KwonDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Robert HromasDepartment of Medicine, University of Texas Health San Antonio, San Antonio, Texas 78229, USA.
Patrick SungDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6M
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
YEAST DNA REPAIR GENES AND PROTEINS OF THE RAD52 GROUPR01ES007061 · NIEHS · YALE UNIVERSITY · PI Patrick Sung · 1995 to 2026
$9.4M
EEPD1 Repair of Stressed Replication ForksR01CA205224 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robert A Hromas · 2016 to 2026
$3.3M
NUCKS, a novel double-strand break repair gene, implicated in cancer biologyR01ES021454 · NIEHS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI WIESE, CLAUDIA · 2012 to 2016
$1.9M
Genome Maintenance via the BRCA-PALB2 Tumor Suppressor NetworkR01CA220123 · NCI · YALE UNIVERSITY · PI SUNG, PATRICK · 2017 to 2019
$1.2M
Mechanisms for Chromosomal TranslocationsR01GM109645 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HROMAS, ROBERT A · 2015 to 2018
$1.2M
NCI NIH HHS P01 CA092584NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA205224NCI NIH HHS R01 CA220123NIEHS NIH HHS R01 ES007061NIEHS NIH HHS R01 ES021454NIGMS NIH HHS R01 GM109645
6 · The paper itself

Abstract

Mutations in the

Indexed as

Gene Regulatory NetworksRecombinational DNA RepairBinding SitesBRCA1 ProteinBRCA2 ProteinBreast NeoplasmsDNADNA Breaks, Double-StrandedDNA ReplicationFemaleGenome, HumanGenomic InstabilityHumansModels, MolecularProtein BindingProtein Structure, SecondaryBARD1 protein, humanBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanDNARAD51 protein, humanRad51 RecombinaseTumor Suppressor ProteinsUbiquitin-Protein LigasesBARD1BRCA1BRCA2DNA damage repairgenome maintenancehomologous recombinationreplication fork protectionreplication fork repairtumor suppression

Identifiers

PMID30917004
PMCPMC7004434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.