Evidence map›Paper›PMID 30916999›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

15-Epi-LXA

Stephanie G Dakin, Romain A Colas, Julia Newton, Stephen Gwilym, Natasha Jones, Hamish A B Reid, Simon Wood, Louise Appleton, Kim Wheway, Bridget Watkins and 2 more

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Achilles tendinopathy.Nature reviews. Disease primers · 2025
    Review
  6. A signaling network map of Lipoxin (LXA4): an anti-inflammatory molecule.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  11. Review
  12. Lipoxin alleviates oxidative stress: a state-of-the-art review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Inflammatory mechanisms linking obesity and tendinopathy.Journal of orthopaedic translation · 2021
    Review
  18. Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Stephanie G DakinNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Romain A ColasLipid Mediator Unit, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Julia NewtonNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Stephen GwilymNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Natasha JonesNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Hamish A B ReidNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Simon WoodNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Louise AppletonNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Kim WhewayNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Bridget WatkinsNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Jesmond DalliLipid Mediator Unit, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Andrew J CarrNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Center, University of Oxford, Oxford, United Kingdom.
Nuffield Orthopaedic Centre · GBUniversity of Oxford · GBQueen Mary University of London · GB

Funding

Medical Research Council MR/J006815/1Wellcome Trust
6 · The paper itself

Abstract

Resolution of inflammation is poorly understood in Achilles tendon disorders. Herein, we investigated the bioactive lipid mediator profiles of tendon-derived stromal cells isolated from patients with Achilles tendinopathy (AT) or Achilles rupture (AR) under baseline and IL-1β-stimulated conditions. We also determined whether incubating these cells with 2 of the mediators produced by tendon-derived stromal cells, 15-epi-Lipoxin A

Indexed as

Achilles TendonAdultAgedArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseBiopsyCells, CulturedDocosahexaenoic AcidsEicosanoidsFemaleGene Expression ProfilingHumansInflammation MediatorsInterleukin-1betaLipoxinsMale7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acidALOX12 protein, humanALOX15 protein, humanArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseDocosahexaenoic AcidsEicosanoidsInflammation MediatorsInterleukin-1betalipoxin A4Lipoxins15-epi-LipoxinAmaresin-1resolutiontendon

Identifiers

PMID30916999
PMCPMC6593888
OpenAlexW2924902948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.