Evidence map›Paper›PMID 30916897›Full record

ArticleJournal of the International AIDS Society2019

Hypertension and diabetes control along the HIV care cascade in rural South Africa.

Jennifer Manne-Goehler, Mark J Siedner, Livia Montana, Guy Harling, Pascal Geldsetzer, Julia Rohr, F Xavier Gómez-Olivé, Alexander Goehler, Alisha Wade, Thomas Gaziano and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the International AIDS Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Dried Blood Spots to Assess Cardiovascular-Kidney-Metabolic Health.Journal of the American Heart Association · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 5 countries.

Jennifer Manne-GoehlerDivision of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mark J SiednerMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Livia MontanaHarvard Center for Population & Development Studies, Harvard University, Cambridge, MA, USA.
Guy HarlingHarvard Center for Population & Development Studies, Harvard University, Cambridge, MA, USA.
Pascal GeldsetzerDepartment of Global Health & Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Julia RohrHarvard Center for Population & Development Studies, Harvard University, Cambridge, MA, USA.
F Xavier Gómez-OlivéMedical Research Council/Wits Rural Public Health & Health Transitions Research Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Alexander GoehlerDepartment of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alisha WadeMedical Research Council/Wits Rural Public Health & Health Transitions Research Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Thomas GazianoDepartment of Cardiovascular Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kathleen KahnMedical Research Council/Wits Rural Public Health & Health Transitions Research Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Justine I DaviesMedical Research Council/Wits Rural Public Health & Health Transitions Research Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Stephen TollmanMedical Research Council/Wits Rural Public Health & Health Transitions Research Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Till W BärnighausenDepartment of Global Health & Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USUniversity of the Witwatersrand · ZAHarvard Global Health Institute · USAfrica Health Research Institute · ZABrigham and Women's Hospital · USIndepth Network · GHKing's College London · GBMassachusetts General Hospital · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Sharon A Nachman · 2011 to 2026
$278.1M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) GroupU01AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI JACKSON, J BROOKS · 2006 to 2010
$109.7M
SOCIAL AND ECONOMIC PREDICTORS OF PHYSICAL AND COGNITIVE FUNCTIONP01AG041710 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI LISA F BERKMAN · 2013 to 2026
$37.3M
Training Tanzanian Researchers for HIV/AIDS Implementation ScienceD43TW009775 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, Christopher Sudfeld · 2015 to 2026
$3.0M
New Methods for the design and evaluation of large HIV prevention interventionsR01AI112339 · NIAID · YALE UNIVERSITY · PI SPIEGELMAN, DONNA L · 2014 to 2017
$2.7M
Causal Pathways to population health impact of HIV antiretroviral treatmentR01HD084233 · NICHD · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2015 to 2021
$2.3M
Can HIV Hot-Spots be eradicated? An intervention to decrease HIV transmission to young women in rural KwaZulu-Natal South AfricaR01AI124389 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2016 to 2020
$2.1M
Endocrine and metabolic diseases in rural South Africa-establishing burden and improving detectionK43TW010698 · FIC · WITS HEALTH CONSORTIUM (PTY), LTD · PI WADE, ALISHA NICOLE · 2017 to 2021
$581k
FIC NIH HHS D43 TW009775FIC NIH HHS K43 TW010698NIAID NIH HHS R01 AI112339NIAID NIH HHS R01 AI124389NIAID NIH HHS U01 AI068632NIAID NIH HHS UM1 AI068632NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI106701NIA NIH HHS P01 AG041710NICHD NIH HHS R01 HD084233Wellcome Trust 058893/Z/99/A
6 · The paper itself

Abstract

introductionParticipation in antiretroviral therapy (ART) programmes has been associated with greater utilization of care for hypertension and diabetes in rural South Africa. The objective of this study was to assess whether people living with HIV on ART with comorbid hypertension or diabetes also have improved chronic disease management indicators.

methodsThe Health and Aging in Africa: a longitudinal study of an INDEPTH Community in South Africa (HAALSI) is a cohort of 5059 adults >40 years old. Enrollment took place between November 2014 and November 2015. The study collected population-based data on demographics, healthcare utilization, height, weight, blood pressure (BP) and blood glucose as well as HIV infection, HIV-1 RNA viral load (VL) and ART exposure. We used regression models to determine whether HIV care cascade stage (HIV-negative, HIV+ /No ART, ART/Detected HIV VL, and ART/Undetectable VL) was associated with diagnosis or treatment of hypertension or diabetes, and systolic blood pressure and glucose among those with diagnosed hypertension or diabetes. ART use was measured from drug level testing on dried blood spots. RESULTS AND DISCUSSION: Compared to people without HIV, ART/Undetectable VL was associated with greater awareness of hypertension diagnosis (adjusted risk ratio (aRR) 1.18, 95% CI: 1.09 to 1.28) and treatment of hypertension (aRR 1.24, 95% CI: 1.10 to 1.41) among those who met hypertension diagnostic criteria. HIV care cascade stage was not significantly associated with awareness of diagnosis or treatment of diabetes. Among those with diagnosed hypertension or diabetes, ART/Undetectable VL was associated with lower mean systolic blood pressure (5.98 mm Hg, 95% CI: 9.65 to 2.32) and lower mean glucose (3.77 mmol/L, 95% CI: 6.85 to 0.69), compared to being HIV-negative.

conclusionsParticipants on ART with an undetectable VL had lower systolic blood pressure and blood glucose than the HIV-negative participants. HIV treatment programmes may provide a platform for health systems strengthening for cardiometabolic disease.

Indexed as

AdultAgedAnti-Retroviral AgentsBlood GlucoseBlood PressureCohort StudiesComorbidityDiabetes MellitusFemaleHIV-1HIV InfectionsHumansHypertensionLongitudinal StudiesMaleMiddle AgedAnti-Retroviral AgentsBlood GlucoseARTdiabeteshealth systemsHIV care cascadehypertension

Identifiers

PMID30916897
PMCPMC6436499
OpenAlexW2930659247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.