Evidence map›Paper›PMID 30916496›Full record

ArticleAsia-Pacific journal of ophthalmology (Philadelphia, Pa.)

Visual Assessment of Aqueous Humor Outflow.

Xiaobin Xie, Goichi Akiyama, Thania Bogarin, Sindhu Saraswathy, Alex S Huang

Abstract read
In one paragraph

Article in Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaobin XieFrom the Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China; and UCLA Department of Ophthalmology, Doheny Eye Institute, Los Angeles, CA, United States.
Goichi Akiyama
Thania Bogarin
Sindhu Saraswathy
Alex S Huang

Funding

Discovery and Characterization of Anterior Sclera Pathology in GlaucomaK08EY024674 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HUANG, ALEX · 2014 to 2018
$1.1M
NEI NIH HHS K08 EY024674
6 · The paper itself

Abstract

In the past decade, many new pharmacological and surgical treatments have become available to lower intraocular pressure (IOP) for glaucoma. The majority of these options have targeted improving aqueous humor outflow (AHO). At the same time, in addition to new treatments, research advances in AHO assessment have led to the development of new tools to structurally assess AHO pathways and to visualize where aqueous is flowing in the eye. These new imaging modalities have uncovered novel AHO observations that challenge traditional AHO concepts. New behaviors including segmental, pulsatile, and dynamic AHO may have relevance to the disease and the level of therapeutic response for IOP-lowering treatments. By better understanding the regulation of segmental, pulsatile, and dynamic AHO, it may be possible to find new and innovative treatments for glaucoma aiming at these new AHO behaviors.

Identifiers

PMID30916496
PMCPMC7028348

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.