ArticleRevista Brasileira de terapia intensiva2019
Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study.
Article in Revista Brasileira de terapia intensiva, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05636202 (The Early Predictive Roles of NLR and NE% in In-hospital Mortality of Septic Patients), which is not on this map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Early Predictive Roles of NLR and NE% in In-hospital Mortality of Septic Patients: a Single-center 13-year Retrospective Study
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Comparison of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for the diagnosis of neonatal sepsis: a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19.Cardiology journal · 2021Pooled it
- Endocan level and its association with glycemic and inflammatory indices in diabetic nephropathy.BMC endocrine disorders · 2026Article
- Discharge neutrophily-to-lymphocyte ratio and its trajectory as predictors of 30-day outcomes in acute heart failure.ESC heart failure · 2026Article
- Cetirizine and Dexamethasone in Sepsis: Insights into Maresin-1 Signaling and Cytokine Regulation.Journal of clinical medicine · 2025Article
- Statistical Study for the Prognostic Value of NLR Values in Patients with Severe Burns: A Study in the Service of Burns in Albania.Annals of burns and fire disasters · 2025Article
- Neutrophil Lymphocyte Ratio and Clinical Outcome in Children Admitted to PICU: A Prospective Observational Study.Indian journal of pediatrics · 2025Observational
- Clinical and Therapeutic Insights into Sepsis: A Retrospective Observational Study of Inflammatory Markers, and Outcomes.Biomedicines · 2025Article
- Urinary tract infections and other associated factors in two Syrian hospitals: a cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
- Exercise-Driven Comprehensive Recovery: Pulmonary Rehabilitation's Impact on Lung Function, Mechanics, and Immune Response in Post-COVID-19 Patients.Infectious disease reports · 2025Article
- The Complete Blood Count Sepsis Index Using Monocyte Distribution Width for Early Detection of Sepsis in Patients Without Obvious Signs.Critical care explorations · 2025Observational
- Developing Augmented Pro-SOFA and Pro-SAPS Models by Integrating Biomarkers PCT, NLR, and CRP with SOFA and SAPS-III Scores.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- The neutrophil-to-lymphocyte ratio levels over time correlate to all-cause hospital mortality in sepsis.Heliyon · 2024Article
- Role of neutrophil-lymphocyte ratio as a prognostic marker in SJS/TEN patients.Archives of dermatological research · 2024Article
- Neutrophil-to-lymphocyte ratio in community-acquired pneumonia: Diagnostic potential and its limitations in the COVID era.Journal of family medicine and primary care · 2024Article
- Understanding the Correlation between Blood Profile and the Duration of Hospitalization in Pediatric Bronchopneumonia Patients: A Cross-Sectional Original Article.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- PROGNOSTIC VALUES OF NEUTROPHIL/LYMPHOCYTE RATIO IN SEVERE BURN PATIENTS.Annals of burns and fire disasters · 2024Article
- Could We Predict Chronic Obstructive Pulmonary Disease Exacerbation Based on Neutrophil to Lymphocyte Count Ratio (NLR)?Tanaffos · 2024Article
- The early predictive roles of NLR and NE% in in-hospital mortality of septic patients.Heliyon · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the neutrophil-lymphocyte ratio as a predictor of sepsis and mortality in patients admitted to an intensive care unit.
methodsCase-control study of adult patients admitted to an intensive care unit. Patients who had sepsis as the reason for admission and who had a previous complete blood count examination were included as case patients. The following statistical analyses were performed: ROC curves, binary logistic regression, and Mann-Whitney and Pearson's chi-square tests. p < 0.05 was considered significant.
resultsThe ROC curve values were 0.62 for neutrophil-lymphocyte ratio, 0.98 for band neutrophils and 0.51 for total leukocytes. The presence of a neutrophil-lymphocyte ratio greater than 5.0, leukocyte count above 12,000mm3/mL and band neutrophil percentage above 10% were risk factors for sepsis; however, only the SAPS 3 and SOFA score were related to patient mortality.
conclusionThe neutrophil-lymphocyte ratio and band neutrophils in combination with other parameters may be markers for the early detection of sepsis in intensive care units.
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