Evidence map›Paper›PMID 30916235›Full record

ArticleRevista Brasileira de terapia intensiva2019

Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study.

Tatiana Helena Rech, Geisiane Custódio, Leonardo Viliano Kroth, Sabrina Frighetto Henrich, Édison Moraes Rodrigues Filho, Daisy Crispim, Cristiane Bauermann Leitão

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista Brasileira de terapia intensiva, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tatiana Helena RechPrograma de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.
Geisiane CustódioPrograma de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.
Leonardo Viliano KrothUnidade de Transplante Renal, Hospital São Lucas - Porto Alegre (RS), Brasil.
Sabrina Frighetto HenrichUnidade de Terapia Intensiva, Hospital São Vicente de Paulo - Passo Fundo (RS), Brasil.
Édison Moraes Rodrigues FilhoUnidade de Terapia Intensiva, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.
Daisy CrispimPrograma de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.
Cristiane Bauermann LeitãoPrograma de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.
Universidade Federal do Rio Grande do Sul · BRHospital São Lucas da PUCRS · BRHospital São Vicente · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the association between donor plasma cytokine levels and the development of primary graft dysfunction of organs transplanted from deceased donors.

methodsSeventeen deceased donors and the respective 47 transplant recipients were prospectively included in the study. Recipients were divided into two groups: group 1, patients who developed primary graft dysfunction; and group 2, patients who did not develop primary graft dysfunction. Donor plasma levels of TNF, IL-6, IL-1β, and IFN-γ assessed by ELISA were compared between groups.

resultsSixty-nine organs were retrieved, and 48 transplants were performed. Donor plasma cytokine levels did not differ between groups (in pg/mL): TNF, group 1: 10.8 (4.3 - 30.8) versus group 2: 8.7 (4.1 - 33.1), p = 0.63; IL-6, group 1: 1617.8 (106.7 - 5361.7) versus group 2: 922.9 (161.7 - 5361.7), p = 0.56; IL-1β, group 1: 0.1 (0.1 - 126.1) versus group 2: 0.1 (0.1 - 243.6), p = 0.60; and IFN-γ, group 1: 0.03 (0.02 - 0.2) versus group 2: 0.03 (0.02 - 0.1), p = 0.93). Similar findings were obtained when kidney transplants were analyzed separately.

conclusionIn this sample of transplant recipients, deceased donor plasma cytokines TNF, IL-6, IL-1β, and IFN-γ were not associated with the development of primary graft dysfunction.

Indexed as

Tissue DonorsAdultAgedBrain DeathCohort StudiesCytokinesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedOrgan TransplantationPrimary Graft DysfunctionProspective StudiesTissue and Organ ProcurementCytokines

Identifiers

PMID30916235
PMCPMC6443307
OpenAlexW2931263329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.