Evidence map›Paper›PMID 30916205›Full record

ArticleArquivos brasileiros de cardiologia2019

Cardiac Evaluation in the Acute Phase of Chagas' Disease with Post-Treatment Evolution in Patients Attended in the State of Amazonas, Brazil.

Jessica Vanina Ortiz, Bruna Valessa Moutinho Pereira, Katia do Nascimento Couceiro, Monica Regina Hosannah da Silva E Silva, Susan Smith Doria, Paula Rita Leite da Silva, Edson da Fonseca de Lira, Maria das Graças Vale Barbosa Guerra, Jorge Augusto de Oliveira Guerra, João Marcos Bemfica Barbosa Ferreira

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arquivos brasileiros de cardiologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Overview of Chagas disease in Amazonas: an integrated approach.Revista da Sociedade Brasileira de Medicina Tropical · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Acute micro-outbreak of Chagas disease in the southeastern Amazon: a report of five cases.Revista da Sociedade Brasileira de Medicina Tropical · 2022
    Article
  11. Article
  12. Article
  13. The Liver and the Hepatic Immune Response inPathogens (Basel, Switzerland) · 2021
    Review
  14. Chagas Disease: Are Kissing Bugs the Only Culprit?Arquivos brasileiros de cardiologia · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jessica Vanina OrtizUniversidade do Estado do Amazonas, Manaus, AM - Brazil.ORCID 0000-0001-7214-6816
Bruna Valessa Moutinho PereiraUniversidade do Estado do Amazonas, Manaus, AM - Brazil.
Katia do Nascimento CouceiroUniversidade do Estado do Amazonas, Manaus, AM - Brazil.
Monica Regina Hosannah da Silva E SilvaFundação de Hematologia e Hemoterapia do Amazonas, Manaus, AM - Brazil.
Susan Smith DoriaUniversidade do Estado do Amazonas, Manaus, AM - Brazil.
Paula Rita Leite da SilvaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM - Brazil.
Edson da Fonseca de LiraFundação de Hematologia e Hemoterapia do Amazonas, Manaus, AM - Brazil.
Maria das Graças Vale Barbosa GuerraUniversidade do Estado do Amazonas, Manaus, AM - Brazil.
Jorge Augusto de Oliveira GuerraUniversidade do Estado do Amazonas, Manaus, AM - Brazil.
João Marcos Bemfica Barbosa FerreiraUniversidade do Estado do Amazonas, Manaus, AM - Brazil.
Fundação de Medicina Tropical · BRUniversidade do Estado do Amazonas · BRFundação Hospitalar de Hematologia e Hemoterapia do Amazonas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the past two decades, a new epidemiological profile of Chagas' disease (CD) has been registered in the Brazilian Amazon where oral transmission has been indicated as responsible for the increase of acute cases. In the Amazonas state, five outbreaks of acute CD have been registered since 2004. The cardiac manifestations in these cases may be characterized by diffuse myocarditis, with alteration in the electrocardiogram (ECG) and transthoracic echocardiogram (TTE).

objectiveTo perform a cardiac evaluation in autochthonous patients in the acute phase and at least one year after submitted to treatment for acute CD and evaluate the demographic variables associated with the presence of cardiac alterations.

methodsWe evaluated patients diagnosed with acute CD through direct parasitological or serological (IgM) methods from 2007 to 2015. These patients were treated with benznidazole and underwent ECG and TTE before and after treatment. We assumed a confidence interval of 95% (CI 95%, p < 0.05) for all variables analyzed.

resultsWe observed 63 cases of an acute CD in which oral transmission corresponded to 75%. Cardiac alterations were found in 33% of the cases, with a greater frequency of ventricular repolarization alteration (13%), followed by pericardial effusion (10%) and right bundle branch block and left anterior fascicular block (2%). The follow-up occurred in 48 patients with ECG and 25 with TTE for a mean period of 15.5 ± 4.1 months after treatment. Of these, 8% presented normalization of the cardiac alterations in ECG, 62.5% remained with the normal exams. All of the patients presented normal results in TTE in the post-treatment period. As for the demographic variables, isolated cases presented more cardiac alterations than outbreaks (p = 0.044) as well as cases from Central Amazonas mesoregion (p = 0.020).

conclusionsAlthough cardiac alterations have not been frequent in most of the studied population, a continuous evaluation of the clinical-epidemiological dynamics of the disease in the region is necessary in order to establish preventive measures.

Indexed as

AdolescentAdultBrazilChagas CardiomyopathyChagas DiseaseEchocardiographyElectrocardiographyFemaleFollow-Up StudiesHumansMaleNitroimidazolesTrypanocidal AgentsTrypanosoma cruziYoung AdultbenzonidazoleNitroimidazolesTrypanocidal Agents

Identifiers

PMID30916205
PMCPMC6424035
OpenAlexW2903687106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.