ArticleBritish journal of anaesthesia2019
Assessing pain in the postoperative period: Analgesia Nociception Index
Article in British journal of anaesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03267979 (Assessing Pain in the Postoperative Period by Automatically Measuring the Variation Coefficient of Pupillary Diameter), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing Pain in the Postoperative Period by Automatically Measuring the Variation Coefficient of Pupillary Diameter: PREVANS Study
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Comparison between Analgesia Nociception Index (ANI) and self-reported measures for diagnosing pain in conscious individuals: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- The Relationship between Pre-Anesthetic Analgesia and Nociception (ANI) and Propofol Injection Pain among Patients Receiving Remifentanil: A Prospective, Randomized, Controlled Study.Medicina (Kaunas, Lithuania) · 2024Trial
- Intraoperative Nociception Monitoring Using the NoL Index: Phase-Specific Assessment of Nociceptive Responses During Spinal Surgery.Journal of clinical medicine · 2025Article
- Predictive machine learning for postoperative pain using biosignals: a retrospective observational study.BMC medical informatics and decision making · 2025Observational
- Is quantitative pupillometry affected by ambient light? A prospective crossover study.Journal of clinical monitoring and computing · 2025Article
- Evaluation of the parasympathetic tone activity (PTA) for posttraumatic pain assessment in awake dogs before orthopaedic surgery - A prospective non-randomised clinical study.BMC veterinary research · 2025Article
- Postoperative multimodal pain management: a narrative review of current practices, clinical and educational gaps, and future directions.Frontiers in anesthesiology · 2025Article
- Preoperative pupillary metrics as predictors of postoperative acute and chronic pain following thoracoscopic surgery: a prospective study.American journal of translational research · 2025Article
- Measurements of pupillary unrest using infrared pupillometry fail to detect changes in pain intensity in patients after surgery: a prospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Observational
- Effect of nose twitching on the pupillary dilation in awake and anesthetized horses.Frontiers in veterinary science · 2024Article
- Assessment of the nociceptive response to the use of cannabidiol alone and in combination with meloxicam through infrared pupillometry in female dogs undergoing elective ovariohysterectomy.Frontiers in veterinary science · 2024Article
- Pain Assessment Using the Analgesia Nociception Index (ANI) in Patients Undergoing General Anesthesia: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2023Review
- Analgesia nociception index and high frequency variability index: promising indicators of relative parasympathetic tone.Journal of anesthesia · 2023Review
- Comparative evaluation of visual analogue scale and pupillary diameter for post-operative pain: An observational study.Indian journal of anaesthesia · 2023Article
- Investigating pupillometry to detect preoperative anxiety: a pilot study.Frontiers in psychology · 2023Article
- Does past/current pain change pain experience? Comparing self-reports and pupillary responses.Frontiers in psychology · 2023Article
- Does the pain sensitivity questionnaire correlate with tourniquet pain in patients undergoing ankle surgery?Frontiers in surgery · 2023Article
- Pupillary unrest, opioid intensity, and the impact of environmental stimulation on respiratory depression.Journal of clinical monitoring and computing · 2022Article
- Relevance of cortisol and copeptin blood concentration changes in an experimental pain model.Scientific reports · 2022Article
- The median effective concentration of remifentanil to inhibit pupillary reflex dilation induced by endotracheal intubation.American journal of translational research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPotential methods for objective assessment of postoperative pain include the Analgesia Nociception Index™ (ANI), a real-time index of the parasympathetic tone, the pupillary light reflex (PLR), and the variation coefficient of pupillary diameter (VCPD), a measure of pupillary diameter (PD) fluctuations. Until now, the literature is divided as to their respective accuracy magnitudes for assessing a patient's pain. The VCPD has been demonstrated to strongly correlate with pain in an obstetrical population. However, the pain induced by obstetrical labour is different, given its intermittent nature, than the pain observed during the postoperative period. The aim of the current study was to compare the respective values of these variables at VAS scores ≥4.
methodsAfter approval by the Ethics Committee, 345 patients aged on average 50 (SD 17) yr (range: 18-91 yr) of age were included. The protocols of general anaesthesia and postoperative analgesia were left to the anaesthetist's discretion. Some 40 min after tracheal intubation, VAS, ANI, PD, PLR, and VCPD values were recorded.
resultsVCPD correlates more strongly (r=0.78) with pain as assessed with the VAS than ANI (r=-0.15). PD and PLR are not statistically correlated with VAS. The ability of VCPD to assess the pain of patients (VAS≥4) is strong [area under the curve (AUC): 0.92, confidence interval (CI): 0.89-0.95], and better than for ANI (AUC: 0.39, CI: 0.33-0.45).
conclusionsOur study suggests that VCPD could be a useful tool for monitoring pain in conscious patients during the postoperative period. CLINICAL
trial registrationNCT03267979.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.