ArticleParasitology2019
Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host.
Article in Parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Uncovering the Burden of Hookworm and Co-Infections in Southeast Asia: A Systematic Review on Human and Small Animal Populations.Acta parasitologica · 2026Pooled it
- Environmental drivers of low vaccine responsiveness in a lab-to-wild rodent model.PLoS pathogens · 2026Article
- Review
- Parasite responses to resource provisioning can be altered by within-host co-infection interactions.Proceedings. Biological sciences · 2025Article
- Coinfection affects the phenotypic but not genetic resistance of cattle to common parasites.Genetics, selection, evolution : GSE · 2025Article
- InvasiveInternational journal for parasitology. Parasites and wildlife · 2024Article
- Large-bodied gastric spirurids (Nematoda, Spirurida) predict structure in the downstream gastrointestinal helminth community of wild spiny mice (Parasitology · 2024Article
- The impact of within-host coinfection interactions on between-host parasite transmission dynamics varies with spatial scale.Proceedings. Biological sciences · 2024Article
- Immunogenetic-pathogen networks shrink in Tome's spiny rat, a generalist rodent inhabiting disturbed landscapes.Communications biology · 2024Article
- A congeneric and non-randomly associated pair of larval trematodes dominates the assemblage of co-infecting parasites in fathead minnows (Parasitology · 2023Article
- Investigating the outcomes of virus coinfection within and across host species.PLoS pathogens · 2023Article
- Altered within- and between-host transmission under coinfection underpin parasite co-occurrence patterns in the wild.Evolutionary ecology · 2023Article
- Coinfection patterns of two marine apicomplexans are not associated with genetic diversity of their polychaete host.The Journal of eukaryotic microbiology · 2023Article
- The genome sequence of the wood mouse,Wellcome open research · 2023Article
- Assessing rates of parasite coinfection and spatiotemporal strain variation via metabarcoding: Insights for the conservation of European turtle doves Streptopelia turtur.Molecular ecology · 2022Article
- Literature Review: Coinfection in Young Ruminant Livestock-Pathogens (Basel, Switzerland) · 2022Review
- Impact of Coinfection with Schistosoma mansoni on the Antibody Response to Helicobacter pylori.Acta parasitologica · 2021Article
- Metabarcoding options to study eukaryotic endoparasites of birds.Ecology and evolution · 2021Article
- Embracing nature's complexity: Immunoparasitology in the wild.Seminars in immunology · 2021Review
- Coupling between tolerance and resistance for two relatedEcology and evolution · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Within-host interactions among coinfecting parasites are common and have important consequences for host health and disease dynamics. However, these within-host interactions have traditionally been studied in laboratory mouse models, which often exclude important variation and use unnatural host-parasite combinations. Conversely, the few wild studies of within-host interactions often lack knowledge of parasite exposure and infection history. Here we exposed laboratory-reared wood mice (Apodemus sylvaticus) that were derived from wild-caught animals to two naturally-occurring parasites (nematode: Heligmosomoides polygyrus, coccidia: Eimeria hungaryensis) to investigate the impact of coinfection on parasite infection dynamics, and to determine if the host immune response mediates this interaction. Coinfection led to delayed worm expulsion and prolonged egg shedding in H. polygyrus infections and lower peak E. hungaryensis oocyst burdens. By comparing antibody levels between wild and colony-housed mice, we also found that wild mice had elevated H. polygyrus-IgG1 titres even if currently uninfected with H. polygyrus. Using this unique wild-laboratory system, we demonstrate, for the first time, clear evidence for a reciprocal interaction between these intestinal parasites, and that there is a great discrepancy between antibody levels measured in the wild vs those measured under controlled laboratory conditions in relation to parasite infection and coinfection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.