Evidence map›Paper›PMID 30915663›Full record

Trial reportBreast cancer research and treatment2019

Two-year follow-up of the OptiTrain randomised controlled exercise trial.

Kate A Bolam, Sara Mijwel, Helene Rundqvist, Yvonne Wengström

2 registry-linked trialsOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 13 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02522260 nacompletednot on this map

OptiTrain - Optimal Training for Women With Breast Cancer During Chemotherapy Treatment

TypeinterventionalSponsorKarolinska InstitutetRan2013 to 2021Enrolled240ConditionsWell BeingArmsResistance and aerobic training, Aerobic training, Standard supportive care
NCT06190600 naactive not recruitingnot on this map

Supervised Physical Activity in Young Women With Early Breast Cancer During Neoadjuvant Chemotherpy

TypeinterventionalSponsorThe Greater Poland Cancer CentreRan2018 to 2026Enrolled40ConditionsBreast CancerArmsHigh Intensity Interval Training (HIIT), neoadjuvant treatment (doxorubicin, cyclophosphamide, paclitaxel, trastuzumab, pertuzumab), Standard Supportive Care
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 13 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
  4. Pooled it
  5. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  6. Pooled it
  7. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Long-term effects of exercise interventions on physical activity in breast cancer patients: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  11. Physical rehabilitation for the management of cancer-related fatigue during cytotoxic treatment: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  12. Pooled it
  13. Pooled it
  14. Trial
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  16. Effects of Tai Chi Chuan on physical function and health in breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  19. Patterns and influencing factors of exercise attendance of breast cancer patients during neoadjuvant chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kate A BolamDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels allé 23, 14183, Stockholm, Sweden. kate.bolam@ki.se.ORCID http://orcid.org/0000-0003-2904-0447
Sara MijwelDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels allé 23, 14183, Stockholm, Sweden.
Helene RundqvistDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Yvonne WengströmDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels allé 23, 14183, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

Cancerfonden 130452Svenska Sällskapet för Medicinsk Forskning 50514The Cancer Society of Stockholm 131242The Swedish Cancer and Traffic Accident Foundation 001225
6 · The paper itself

Abstract

purposeThe aim of this study was to determine if there were any differences in health-related outcomes and physical activity (PA) between the two OptiTrain exercise groups and usual care (UC), 2 years post-baseline.

methodsThe OptiTrain study was a three-arm randomised controlled trial comparing 16 weeks of concurrent aerobic high-intensity interval training (HIIT) and progressive resistance exercise (RT-HIIT) or concurrent HIIT and continuous moderate-intensity aerobic exercise (AT-HIIT) to UC in 206 patients with breast cancer undergoing chemotherapy. Eligible participants were approached 2 years following baseline to assess cancer-related fatigue, quality of life, symptoms, muscle strength, cardiorespiratory fitness, body mass, PA, sedentary behaviour, and sick leave.

resultsThe RT-HIIT group reported lower total cancer-related fatigue, (- 1.37, 95% CI - 2.70, - 0.04, ES = - 0.06) and cognitive cancer-related fatigue (- 1.47, 95% CI - 2.75, - 0.18, ES = - 0.28), and had higher lower limb muscle strength (12.09, 95% CI 3.77, 20.40, ES = 0.52) than UC at 2 years. The AT-HIIT group reported lower total symptoms (- 0.23, 95% CI - 0.42, - 0.03, ES = - 0.15), symptom burden (- 0.30, 95% CI - 0.60, - 0.01, ES = - 0.19), and body mass - 2.15 (- 3.71, - 0.60, ES = - 0.28) than UC at 2 years.

conclusionAt 2 years, the exercise groups were generally experiencing positive differences in cancer-related fatigue (RT-HIIT), symptoms (AT-HIIT), and muscle strength (RT-HIIT) to UC. The findings provide novel evidence that being involved in an exercise program during chemotherapy can have long-term benefits for women with breast cancer, but that strategies are needed to create better pathways to support patients to maintain physical activity levels.

trial registrationClinicaltrials.gov registration number: NCT02522260. Trial registered on 9 June 2015. https://clinicaltrials.gov/ct2/show/NCT02522260 . Retrospectively registered.

Indexed as

AdultAgedBody Mass IndexBreast NeoplasmsCardiorespiratory FitnessDrug TherapyFatigueFemaleFollow-Up StudiesHigh-Intensity Interval TrainingHumansMiddle AgedQuality of LifeResistance TrainingRetrospective StudiesSick LeaveBreast cancerChemotherapyExerciseFatigueLong-term effectsPhysical activity

Identifiers

PMID30915663
PMCPMC6534518
OpenAlexW2924012992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.