ArticleEuropean radiology2019
Whole-body MRI vs bone scintigraphy in the staging of Ewing sarcoma of bone: a 12-year single-institution review.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- ESR Essentials: bone marrow MRI in oncology-practice recommendations by the European Society of Musculoskeletal Radiology.European radiology · 2026Guideline
- Whole-body MRI for staging and follow-up of primary musculoskeletal tumours: a systematic review.The British journal of radiology · 2026Pooled it
- Clinical practice guidelines for the treatment of Ewing sarcoma (Spanish Sarcoma Research Group-GEIS).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Guideline
- Imaging of ewing sarcoma: an updated analysis including presenting features, prognostic imaging biomarkers, and treatment response assessment.Skeletal radiology · 2026Review
- Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment.Molecular cancer · 2024Review
- Imaging of pediatric bone tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper.Pediatric blood & cancer · 2023Article
- Skip metastases in high-grade intramedullary appendicular osteosarcoma: an indicator of more aggressive disease?Skeletal radiology · 2021Article
- Repeatability and reproducibility of ADC measurements: a prospective multicenter whole-body-MRI study.European radiology · 2021Article
- Review
- Skeletal staging in Langerhans cell histiocytosis: a multimodality imaging review.Skeletal radiology · 2021Review
- The value of chest and skeletal staging studies in conventional chondrosarcoma.Skeletal radiology · 2021Article
- Langerhans cell histiocytosis of the shoulder girdle, pelvis and extremities: a review of radiographic and MRI features in 85 cases.Skeletal radiology · 2020Review
- Seeking international consensus on approaches to primary tumour treatment in Ewing sarcoma.Clinical sarcoma research · 2020Article
- [The importance of radiology in bone sarcoma diagnostics : Initial and advanced diagnostics].Der Orthopade · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare whole-body MRI (WB-MRI) at 1.5/3T and bone scintigraphy in the skeletal staging of Ewing sarcoma (ES) of bone.
methodsAll patients with a histological diagnosis of ES of bone between 2007 and 2018 were retrospectively reviewed. The analysis included gender, mean age, skeletal distribution, and prevalence of skeletal metastases on WB-MRI and bone scintigraphy.
resultsThe study group comprised 182 patients with a mean age of 18.0 years (range 2-56 years), 126 males and 56 females. Skeletal metastases were detected overall in 30 patients (16.5%), in 23 of 96 patients (24%) who underwent WB-MRI, and in 20 of 118 patients (16.9%) who underwent bone scintigraphy. Of 71 patients who underwent both WB-MRI and bone scintigraphy, skeletal metastases were detected on both modalities in 13 (18.3%), while in 4 patients, skeletal metastases were identified on WB-MRI alone. There were no patients in whom skeletal metastases were identified on bone scintigraphy alone. Of 13 patients with skeletal metastases who underwent both studies, WB-MRI showed a greater number of metastatic foci in 10 (76.9%). However, scintigraphy was superior to WB-MRI in detecting skull vault lesions, but did show false-positive results around the long bone growth plates.
conclusionWB-MRI is more sensitive than bone scintigraphy in detecting skeletal metastases in ES of bone, with the exception of skull vault metastases. Consideration should be given to replacing bone scintigraphy with WB-MRI. KEY POINTS: • Whole-body MRI is more sensitive than bone scintigraphy in detecting skeletal metastases in Ewing sarcoma of bone. • Whole-body MRI can safely replace bone scintigraphy for staging of the skeleton, with the acknowledgement of the possibility of missing a clinically occult skull vault metastasis.
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