Evidence map›Paper›PMID 30915523›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

PET/CT radiomics in breast cancer: promising tool for prediction of pathological response to neoadjuvant chemotherapy.

Lidija Antunovic, Rita De Sanctis, Luca Cozzi, Margarita Kirienko, Andrea Sagona, Rosalba Torrisi, Corrado Tinterri, Armando Santoro, Arturo Chiti, Renata Zelic and 1 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Clinicopathological and molecular predictors of [European journal of nuclear medicine and molecular imaging · 2024
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  11. Identification of HER2-over-expression, HER2-low-expression, and HER2-zero-expression statuses in breast cancer based onCancer imaging : the official publication of the International Cancer Imaging Society · 2025
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  14. La Radiologia medica · 2025
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lidija AntunovicDepartment of Nuclear Medicine, Humanitas Clinical and Research Center- IRCCS, via Manzoni 56, 20089, Rozzano, Milan, Italy. lidija.antunovic@humanitas.it.ORCID http://orcid.org/0000-0003-1832-1083
Rita De SanctisDepartment of Medical Oncology and Hematology, Humanitas Clinical and Research Center- IRCCS, Rozzano, Milan, Italy.
Luca CozziDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Margarita KirienkoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Andrea SagonaBreast Surgery Department, Humanitas Clinical and Research Center- IRCCS, Rozzano, Milan, Italy.
Rosalba TorrisiDepartment of Medical Oncology and Hematology, Humanitas Clinical and Research Center- IRCCS, Rozzano, Milan, Italy.
Corrado TinterriBreast Surgery Department, Humanitas Clinical and Research Center- IRCCS, Rozzano, Milan, Italy.
Armando SantoroDepartment of Medical Oncology and Hematology, Humanitas Clinical and Research Center- IRCCS, Rozzano, Milan, Italy.
Arturo ChitiDepartment of Nuclear Medicine, Humanitas Clinical and Research Center- IRCCS, via Manzoni 56, 20089, Rozzano, Milan, Italy.
Renata ZelicClinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Martina SolliniDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the role of radiomics parameters in predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer.

methodsSeventy-nine patients who had undergone pretreatment staging

resultsNineteen patients (24%) had pCR to NAC. Different models were generated on complete information and imputed datasets, using univariable and multivariable logistic regression and least absolute shrinkage and selection operator (lasso) regression. All models could predict pCR to NAC, with area under the curve values ranging from 0.70 to 0.73. All models agreed that tumor molecular subtype is the primary predictor of the primary endpoint.

conclusionsOur models predicted that patients with subtype 2 and subtype 3 (HER2+ and triple negative, respectively) are more likely to have a pCR to NAC than those with subtype 1 (luminal). The association between PET imaging features and pCR suggested that PET imaging features could be considered as potential predictors of pCR in locally advanced breast cancer patients.

Indexed as

Chemotherapy, AdjuvantNeoadjuvant TherapyPositron Emission Tomography Computed TomographyAgedBreast NeoplasmsCalibrationFemaleFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedMiddle AgedMultivariate AnalysisOdds RatioPrognosisRadiopharmaceuticalsRegression AnalysisFluorodeoxyglucose F18Radiopharmaceuticals18F-FDG PET/CTAdvanced featuresBreast cancerNeoadjuvant chemotherapyRadiomicsTreatment response prediction

Identifiers

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Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.