Evidence map›Paper›PMID 30915522›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Clinical impact of [

Antoine Leuzy, Irina Savitcheva, Konstantinos Chiotis, Johan Lilja, Pia Andersen, Nenad Bogdanovic, Vesna Jelic, Agneta Nordberg

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05374564 (Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05374564 phase1completednot on this mapstarted 2022, after this paper: background citation

Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy

TypeinterventionalSponsorYale UniversityRan2022 to 2024Enrolled12ConditionsCardiomyopathies, PrimaryArms(18F)Flutemetamol
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Outcomes of clinical utility in amyloid-PET studies: state of art and future perspectives.European journal of nuclear medicine and molecular imaging · 2021
    Pooled it
  2. Review
  3. Article
  4. A brief history of Aβ imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  5. Article
  6. Review
  7. Ultra-fast [EJNMMI physics · 2024
    Article
  8. Article
  9. Incremental value of amyloid PET in a tertiary memory clinic setting in China.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Alzheimer's Dementia: The Emerging Role of Positron Emission Tomography.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022
    Review
  14. Article
  15. Quantification of amyloid PET for future clinical use: a state-of-the-art review.European journal of nuclear medicine and molecular imaging · 2022
    Review
  16. Article
  17. Article
  18. Relationship between amyloid and tau levels and its impact on tau spreading.European journal of nuclear medicine and molecular imaging · 2021
    Article
  19. Review
  20. Clinical impact ofEuropean journal of nuclear medicine and molecular imaging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Antoine LeuzyDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics Center for Alzheimer Research, Karolinska Institutet, Neo, 7th floor, 141 83, Huddinge, Sweden.
Irina SavitchevaMedical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.
Konstantinos ChiotisDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics Center for Alzheimer Research, Karolinska Institutet, Neo, 7th floor, 141 83, Huddinge, Sweden.
Johan LiljaDepartment of Surgical Sciences, Radiology, Nuclear Medicine and PET, Uppsala University, Uppsala, Sweden.
Pia AndersenClinic for Cognitive Disorders, Theme Aging, Karolinska University Hospital, Stockholm, Sweden.
Nenad BogdanovicClinic for Cognitive Disorders, Theme Aging, Karolinska University Hospital, Stockholm, Sweden.
Vesna JelicDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics Center for Alzheimer Research, Karolinska Institutet, Neo, 7th floor, 141 83, Huddinge, Sweden.
Agneta NordbergDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics Center for Alzheimer Research, Karolinska Institutet, Neo, 7th floor, 141 83, Huddinge, Sweden. agneta.k.nordberg@ki.se.
Karolinska University Hospital · SEKarolinska Institutet · SEHermes Medical Solutions (Sweden) · SE

Funding

Swedish Research Council 05817, 02695, 06086
6 · The paper itself

Abstract

purposeTo investigate the impact of amyloid PET with [

methodsThe study population consisted of 207 patients with a clinical diagnosis prior to [

resultsAmyloid positivity was found in 53% of MCI, 68% of AD, 20% of non-AD, 20% of dementia NOS, and 60% of SCD patients. [

conclusionThe present study lends support to the clinical value of amyloid PET in patients with an uncertain diagnosis in the tertiary memory clinic setting.

Indexed as

Positron-Emission TomographyAgedAlzheimer DiseaseAmyloidAniline CompoundsBenzothiazolesBiomarkersBrainCerebrospinal FluidCholinesterase InhibitorsCognition DisordersCognitive DysfunctionCohort StudiesDementiaFemaleHumansAmyloidAniline CompoundsBenzothiazolesBiomarkersCholinesterase InhibitorsflutemetamolRadiopharmaceuticals[18F]FlutemetamolAlzheimer’s diseaseAmyloid PETCholinesterase inhibitorsDiagnostic change

Identifiers

PMID30915522
PMCPMC6486908
OpenAlexW2922927440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.