ArticleEuropean journal of clinical pharmacology2019
Medication and medical diagnosis as risk factors for falls in older hospitalized patients.
Article in European journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- A novel multistep approach to standardize the reported risk factors for in-hospital falls: a proof-of-concept study.Frontiers in public health · 2024Pooled it
- [Recommendations of the second update of the LONTS guidelines : Long-term opioid therapy for chronic noncancer pain].Schmerz (Berlin, Germany) · 2020Pooled it
- The interplay of risk factors for future falls and fall-related injuries among community-dwelling older adults: a Bayesian network analysis.BMC public health · 2026Article
- Psychotropic medication and in-hospital falls in older adults: a cohort-based secondary analysis with exploratory stratification among users.Scientific reports · 2025Article
- Evoked craving in high-dose benzodiazepine users.Frontiers in psychiatry · 2025Article
- Falls in hospitalized older adults and the use of fall risk-increasing drugs and anticholinergic medications in Colombia: a case‒control study.Frontiers in pharmacology · 2024Article
- Prioritising patients for hospital occupational therapy to reduce inpatient falls: A retrospective case-control study to identify predictive patient falls risk factors.The British journal of occupational therapy · 2023Article
- Standardizing default electronic health record tools to improve safety for hospitalized patients with Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Falls in oldest-old adults hospitalized in acute geriatric ward.European geriatric medicine · 2022Article
- Propensity score-matching analysis comparing safety outcomes of appetite-stimulating medications in oncology patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Hip, vertebral, and wrist fracture risks and schizophrenia: a nationwide longitudinal study.BMC psychiatry · 2022Article
- Current practice in benzodiazepine receptor agonists deprescribing on acute geriatric wards: a cohort study.BMC geriatrics · 2022Article
- Study protocol-Evoked craving in high-dose benzodiazepine users.Frontiers in psychiatry · 2022Article
- Polysubstance Use Patterns Among High Dose Benzodiazepine Users: A Latent Class Analysis and Differences Between Male and Female Use.Frontiers in psychiatry · 2022Article
- Fall predictors beyond fall risk assessment tool items for acute hospitalized older adults: a matched case-control study.Scientific reports · 2021Article
- Testing of Reliability and Validity of the Peninsula Health Falls Risk Assessment Tool (PHFRAT) in Acute Care: A Cross-Sectional Study.Risk management and healthcare policy · 2021Article
- Unit-level variation in bed alarm use in US hospitals.Research in nursing & health · 2020Observational
- Why Z-drugs are used even if doctors and nurses feel unable to judge their benefits and risks-a hospital survey.European journal of clinical pharmacology · 2020Article
- Detoxification Improves Multidomain Cognitive Dysfunction in High-Dose Benzodiazepine Abusers.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the impact of medication and medical conditions on the fall risk in older hospitalized patients.
designMatched case-control study.
settingLarge regional hospital in a mid-sized German city. SUBJECTS: Four hundred eighty-one inpatients aged ≥ 65 years who fell during hospitalization ("cases") and a control group of 481 controls, matched for age, gender, and hospital department.
methodsDiagnosis, medication, vital parameters, and injuries were compared between cases and controls. Univariate and multivariable odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. MAIN
resultsSeveral drugs were significantly associated with falls in multivariate analyses: long-acting benzodiazepines (adjusted OR = 3.49; 95%-CI = 1.16-10.52), serotonin-noradrenalin reuptake inhibitors (SNRI) (2.57; 1.23-5.12), Z-drugs (2.29; 1.38-3.59), low-potency neuroleptics (1.87; 1.08-3.23), ACE inhibitors/sartans (1.42; 1.07-1.89). Digoxin (0.32; 0.11-0.99) and aldosterone receptor antagonists (0.54; 0.33-0.88) were negatively associated with falls. No significant association in multivariate analyses was found for short- and intermediate-acting benzodiazepines, mirtazapine, and opioids. Hyponatremia (1.52; 1.15-2.03) and leukocytosis (1.39; 1.05-1.87) in blood examination on admission showed significant association with falls. As secondary diagnoses, Parkinson syndrome (2.38; 1.27-4.46) and delirium (3.74; 2.26-6.21) were strongly associated with falls. The use of more than one psychoactive drug was a separate risk factor for falls (p < 0.0001).
conclusionSeveral drugs including SNRI, neuroleptics, and Z-drugs showed a significant association with inpatient falls. The frequently prescribed tetracyclic antidepressant mirtazapine did not appear to increase the risk of falls. Psychoactive polypharmacy should be avoided.
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