Evidence map›Paper›PMID 30915273›Full record

ArticleFrontiers in oncology2019

Phase II Trial of Cabozantinib Plus Erlotinib in Patients With Advanced Epidermal Growth Factor Receptor (

Karen L Reckamp, Paul H Frankel, Nora Ruel, Philip C Mack, Barbara J Gitlitz, Tianhong Li, Marianna Koczywas, Shirish M Gadgeel, Mihaela C Cristea, Chandra P Belani and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
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  6. Article
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  10. Anticancer drugs: How to select small molecule combinations?Trends in pharmacological sciences · 2024
    Review
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  19. Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Karen L ReckampCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Paul H FrankelCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Nora RuelCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Philip C MackUniversity of California Davis Comprehensive Cancer Center, Sacramento, CA, United States.
Barbara J GitlitzUSC Norris Comprehensive Cancer Center, Los Angeles, CA, United States.
Tianhong LiUniversity of California Davis Comprehensive Cancer Center, Sacramento, CA, United States.
Marianna KoczywasCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Shirish M GadgeelKarmanos Cancer Institute, Wayne State University, Detroit, MI, United States.
Mihaela C CristeaCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Chandra P BelaniPenn State Hershey Cancer Institute, Hershey, PA, United States.
Edward M NewmanCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
David R GandaraUniversity of California Davis Comprehensive Cancer Center, Sacramento, CA, United States.
Primo N LaraUniversity of California Davis Comprehensive Cancer Center, Sacramento, CA, United States.
City of Hope · USUniversity of California, Davis · USPenn State Milton S. Hershey Medical Center · USThe Barbara Ann Karmanos Cancer Institute · USUC Davis Comprehensive Cancer CenterUSC Norris Comprehensive Cancer Center · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
Phase I Molecular and Clinical Pharmacodynamic Trials ETCTNUM1CA186717 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI A. Dimitrios Colevas, Alexey V. Danilov · 2014 to 2026
$19.8M
NCI NIH HHS P30 CA033572NCI NIH HHS P30 CA093373NCI NIH HHS UM1 CA186717
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

EGFRMETnon-small cell lung cancerRETTKI resistanceVEGF

Identifiers

PMID30915273
PMCPMC6421302
OpenAlexW2921800184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.