ReviewBiomaterials research2019
Review of bone graft and bone substitutes with an emphasis on fracture surgeries.
Review in Biomaterials research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 241 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
241 citing papers in PubMed, 3 syntheses or guidelines pooled it, 490 citations in OpenAlex.
- Revolutionizing Bone Regeneration with Grinder-Based Dentin Biomaterial: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Bone marrow aspirate and bone marrow aspirate concentrate: Does the literature support use in long-bone nonunion and provide new insights into mechanism of action?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Pooled it
- Effectiveness of synthetic versus autologous bone grafts in foot and ankle surgery: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2024Pooled it
- Antral membrane balloon technique versus Densah bur in crestal sinus lift with simultaneous implant placement: a randomized clinical trial.BMC oral health · 2024Trial
- Long-Term Bone Healing Using Autogenous Tooth Bone Graft Combined with rhBMP-2 after Enucleation of a Large Odontogenic Keratocyst: A Case Report.Tissue engineering and regenerative medicine · 2026Article
- Fracture healing: from molecular and cellular mechanisms to therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Twenty-Five-Year Failure of Spinal Allograft Incorporation in Chronic Spinal Hydatid Disease: A Case Report.International journal of spine surgery · 2026Article
- Angiogenic and Osteogenic Strategies for Skeletal Regeneration in Aging.Current osteoporosis reports · 2026Review
- Functionalized 3D-Printed PCL/β-TCP Scaffolds with ZnO for Enhanced Bone Healing.Macromolecular bioscience · 2026Article
- A Functional TGF-β/Smad Assay for Targeted Profiling of Demineralized Bone Matrix-Derived Allograft Bioactivity.Journal of functional biomaterials · 2026Article
- Article
- Strategic Placement of Pores to Modulate Toughness in Hydroxyapatite Bone Scaffolds Fixation.Biomimetics (Basel, Switzerland) · 2026Article
- Combined High Hydrostatic Pressure and Additive Chemical Treatment Enhances Decontamination Efficiency in Bone Tissue Infected with Staphylococcal Biofilms.Microorganisms · 2026Article
- Copper-Doped Silicate Porous Architectures for Hard Tissue Engineering.Journal of functional biomaterials · 2026Article
- Removal of aging microenvironment of bone defects can effectively promote bone defect repair.Journal of translational medicine · 2026Article
- Effects of melatonin and vitamin E on bone healing following alloplastic grafting in osteoporotic cranial bone defects: an experimental study.BMC oral health · 2026Article
- Combining Fluid Dynamics and Biological Experiments to Explore the More Suitable Porosity for Bone Inducing Porous Tantalum Scaffolds.Orthopaedic surgery · 2026Article
- 3D-Printed PLA/HA Composite Scaffolds: Balancing Mechanical Properties for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Article
- Apelin-13 enhances BMSCs osteogenic differentiation and bone regeneration under hypoxia via upregulation of Ibsp.Stem cell research & therapy · 2026Article
- Histological Study of a Novel 3D-Printed Hydroxyapatite/PLGA Bone Graft in the Regeneration of Critical-Sized Long Bone Defects.Bioengineering (Basel, Switzerland) · 2026Article
181 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutogenous bone graft is the gold standard bone graft material. However, due to limitations of supply and morbidity associated with autograft harvest, various bone substitutes have been considered. This article aims to review the properties of the bone graft and various bone substitutes currently available in orthopedic surgery. MAIN BODY: Synthetic bone substitutes consist of hydroxyapatite, tricalcium phosphate, calcium sulfate, or a combination of these minerals. Synthetic porous substitutes share several advantages over allografts, including unlimited supply, easy sterilization, and storage. However, they also have some disadvantages, such as brittle properties, variable rates of resorption, and poor performance in some clinical conditions. Recently, attention has been drawn to osteoinductive materials, such as demineralized bone matrix and bone morphogenetic proteins.
conclusionDespite tremendous efforts toward developing autograft alternatives, a single ideal bone graft substitute has not been developed. The surgeon should understand the properties of each bone graft substitute to facilitate appropriate selection in each specific clinical situation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.