ArticleMultiple sclerosis journal - experimental, translational and clinical
Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Pediatric Radiologically Isolated Syndrome (RIS): A Case with Active Disease 18 Years Later.Neurology and therapy · 2026Article
- Cerebellar Involvement in Immune-Mediated Pediatric Acute Ataxia: Clinical Spectrum, MRI Findings, and Predictors of MOG Antibody Positivity.Cerebellum (London, England) · 2026Article
- Anticipating Clinical Onset in Multiple Sclerosis: Challenges and Opportunities.Journal of personalized medicine · 2025Review
- Influence of age and sex on presymptomatic phases of neurodegenerative diseases: Focus on multiple sclerosis and Alzheimer's disease.Revue neurologique · 2025Review
- The Kappa Free Light Chains Index and Central Vein Sign: Two New Biomarkers for Multiple Sclerosis Diagnosis.Neurology and therapy · 2025Review
- Review
- The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex.Journal of neurology · 2024Article
- Radiologically isolated syndrome in the spectrum of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Review
- The radiologically isolated syndrome: revised diagnostic criteria.Brain : a journal of neurology · 2023Article
- Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report.Frontiers in neurology · 2023Article
- Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis.Current microbiology · 2022Review
- Accumulative risk of clinical event in high-risk radiologically isolated syndrome in Argentina: data from the nationwide registry RelevarEM.Journal of neurology · 2022Article
- Biological Markers in Early Multiple Sclerosis: the Paved Way for Radiologically Isolated Syndrome.Frontiers in immunology · 2022Review
- Secondary Prevention in Radiologically Isolated Syndromes and Prodromal Stages of Multiple Sclerosis.Frontiers in neurology · 2022Review
- Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- The multiple sclerosis prodrome.Nature reviews. Neurology · 2021Review
- Radiologically Isolated Syndrome: A Review for Neuroradiologists.AJNR. American journal of neuroradiology · 2020Review
- Immune signatures of prodromal multiple sclerosis in monozygotic twins.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Current Advances in Pediatric Onset Multiple Sclerosis.Biomedicines · 2020Review
- Epstein-Barr Virus and Multiple Sclerosis.Frontiers in immunology · 2020Review
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Authors and funding
32 authors at 20 institutions in 9 countries.
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Abstract
backgroundSteps towards the development of diagnostic criteria are needed for children with the radiologically isolated syndrome to identify children at risk of clinical demyelination.
objectivesTo evaluate the 2005 and 2016 MAGNIMS magnetic resonance imaging criteria for dissemination in space for multiple sclerosis, both alone and with oligoclonal bands in cerebrospinal fluid added, as predictors of a first clinical event consistent with central nervous system demyelination in children with radiologically isolated syndrome.
methodsWe analysed an international historical cohort of 61 children with radiologically isolated syndrome (≤18 years), defined using the 2010 magnetic resonance imaging dissemination in space criteria (Ped-RIS) who were followed longitudinally (mean 4.2 ± 4.7 years). All index scans also met the 2017 magnetic resonance imaging dissemination in space criteria.
resultsDiagnostic indices (95% confidence intervals) for the 2005 dissemination in space criteria, with and without oligoclonal bands, were: sensitivity 66.7% (38.4-88.2%) versus 72.7% (49.8-89.3%); specificity 83.3% (58.6-96.4%) versus 53.9% (37.2-69.9%). For the 2016 MAGNIMS dissemination in space criteria diagnostic indices were: sensitivity 76.5% (50.1-93.2%) versus 100% (84.6-100%); specificity 72.7% (49.8-89.3%) versus 25.6% (13.0-42.1%).
conclusionsOligoclonal bands increased the specificity of magnetic resonance imaging criteria in children with Ped-RIS. Clinicians should consider testing cerebrospinal fluid to improve diagnostic certainty. There is rationale to include cerebrospinal fluid analysis for biomarkers including oligoclonal bands in planned prospective studies to develop optimal diagnostic criteria for radiologically isolated syndrome in children.
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