Evidence map›Paper›PMID 30915121›Full record

ArticleJournal of oncology2019

Colon Cancer Sidedness, Presentation, and Survival at Different Stages.

Mark B Ulanja, Mohit Rishi, Bryce D Beutler, Mokshya Sharma, Darryll R Patterson, Nageshwara Gullapalli, Santhosh Ambika

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
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  8. Expression of VISTA on T cells in patients with cancer colon.Journal of the Egyptian National Cancer Institute · 2025
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  12. Age as a Predictor of Overall Survival in Colorectal Cancer.Diagnostics (Basel, Switzerland) · 2024
    Article
  13. Integrated molecular profiling ofJournal of gastrointestinal oncology · 2024
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mark B UlanjaUniversity of Nevada, Reno School of Medicine, Department of Internal Medicine, 1155 Mill Street, W-11, Reno, NV 89502, USA.ORCID 0000-0001-5966-3966
Mohit RishiUniversity of Nevada, Reno School of Medicine, Department of Internal Medicine, 1155 Mill Street, W-11, Reno, NV 89502, USA.
Bryce D BeutlerUniversity of Nevada, Reno School of Medicine, Department of Internal Medicine, 1155 Mill Street, W-11, Reno, NV 89502, USA.
Mokshya SharmaUniversity of Nevada, Reno School of Medicine, Department of Internal Medicine, 1155 Mill Street, W-11, Reno, NV 89502, USA.
Darryll R PattersonUniversity of Nevada, Reno School of Medicine, Department of Internal Medicine, 1155 Mill Street, W-11, Reno, NV 89502, USA.
Nageshwara GullapalliUniversity of Nevada, Reno School of Medicine, Department of Internal Medicine, 1155 Mill Street, W-11, Reno, NV 89502, USA.
Santhosh AmbikaUniversity of Nevada, Reno School of Medicine, Department of Internal Medicine, 1155 Mill Street, W-11, Reno, NV 89502, USA.
University of Nevada, Reno · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral prognostic factors have been used to guide therapy for colon cancer (CC). However, the relationship between CC laterality (sidedness) and prognosis remains under investigation.

objectivesTo assess the effect of laterality on CC presentation and survival, using a Surveillance, Epidemiology, and End Results (SEER) population-based cohort.

methodsA retrospective cohort study using data from the SEER program (2007-2015).

resultsOf the 163,980 patients with CC, 85,779 (52.3%) presented with right-sided CC (RCC) and 78,201 (47.7%) with left-sided CC (LCC). Stage distributions were as follows: stage I, 24.1%; stage II, 27.3%; stage III, 28.2%; and stage IV, 20.4%. In an adjusted modified Poisson regression approach for risk ratio (RR), patients with LCCs were more likely to be male (RR = 1.14; 95% CI 1.12-1.15, p<0.001). As compared to stage I, stage II cancers (RR = 0.88, 95% CI 0.87-0.90, p<0.001) were less likely to be LCC. Stage IV CC was slightly less likely to be left-sided (RR = 0.98, 95% CI 0.98, 0.96-1.00, p = 0.028). The median overall survival (OS) for RCC was 87 months. The median OS for LCC was not established, as more than half of the patients diagnosed with LCC were still living at the time of the analysis. In adjusted Cox proportional Hazard model, individuals with stage I, III, and IV LCCs had superior OS as compared to those with matched-stage RCC (adjusted HR = 0.87; 95% CI 0.85-0.88, p<0.001). However, OS was worse among those with stage II disease who presented with LCC (adjusted Hazard ratio [aHR] = 1.06; 95% CI 1.02-1.11, p = 0.004). CC-specific survival (CSS) was superior for LCC versus RCC for stages III and IV but worse for II.

conclusionsIn this population-cohort study, LCC is associated with superior OS and CSS survival. The overall survival advantage was attributed to stage I, III, and IV disease. Individuals presenting with stage II disease exhibit superior survival if the CC is right-sided.

Identifiers

PMID30915121
PMCPMC6409047
OpenAlexW2916784321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.