Evidence map›Paper›PMID 30915116›Full record

ArticleInternational journal of endocrinology2019

An Update of the Appropriate Treatment Strategies in Anaplastic Thyroid Cancer: A Population-Based Study of 735 Patients.

Nai-Si Huang, Xiao Shi, Bo-Wen Lei, Wen-Jun Wei, Zhong-Wu Lu, Peng-Cheng Yu, Yu Wang, Qing-Hai Ji, Yu-Long Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. The efficacy of various treatment modalities and their combinations in improving survival outcomes for anaplastic thyroid cancer: a systematic review and network meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nai-Si Huang *Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.ORCID 0000-0001-7623-5744
Xiao Shi *Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Bo-Wen LeiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Wen-Jun WeiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Zhong-Wu LuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Peng-Cheng YuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Yu WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Qing-Hai JiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.ORCID 0000-0002-4376-0937
Yu-Long WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.ORCID 0000-0002-4100-1443
Shanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnaplastic thyroid cancer (ATC) responds poorly to conventional therapies and requires a multidisciplinary approach to manage. The aim of the current study is to explore whether aggressive treatment is beneficial, especially the appropriate extent of surgery in ATC.

methodsPatients diagnosed with ATC from 2004 to 2014 were identified from the Surveillance, Epidemiology, and End Results (SEER) database and included in our study.

resultsA total of 735 ATC patients were identified. The two-year overall survival (OS) rates for stage IVA, IVB, and IVC patients were 36.5%, 15.6%, and 1.4%, respectively. By directly comparing eight treatment modalities, we found that surgery + radiotherapy (RT) ± chemotherapy was the most effective treatment strategy. surgery + chemotherapy and RT + chemotherapy had comparable results (hazard ratio (HR) = 1.461, 95% confidential interval (CI): 0.843-2.531,

conclusionsIn operable cases, surgery + RT ± chemotherapy was the optimal treatment modality. Otherwise, RT + chemotherapy was the appropriate strategy. However, TT was not beneficial for very early stage or metastatic ATC.

Identifiers

PMID30915116
PMCPMC6399533
OpenAlexW2915787841

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.