Evidence map›Paper›PMID 30914953›Full record

ArticleFrontiers in pharmacology2019

Harnessing Liposome Interactions With the Immune System for the Next Breakthrough in Cancer Drug Delivery.

Ninh M La-Beck, Xinli Liu, Laurence M Wood

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Liposomes in tumor treatment: a double-edged sword.Science China. Life sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ninh M La-BeckDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX, United States.
Xinli LiuDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, United States.
Laurence M WoodDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX, United States.
Texas Tech University · USTexas Tech University Health Sciences Center · USUniversity of Houston · US

Funding

FOXA1 inhibitors to overcome endocrine resistance in ER+ breast cancerP20CA221731 · NCI · UNIVERSITY OF HOUSTON · PI CHOW, DIANA S-L. · 2018 to 2021
$1.1M
FOXA1 inhibitors to overcome endocrine resistance in ER+ breast cancerP20CA221729 · NCI · BAYLOR COLLEGE OF MEDICINE · PI YUSTEIN, JASON · 2018 to 2021
$1.0M
Novel Therapeutics Targeting HER2 Positive Breast Cancer Brain MetastasisR15CA182769 · NCI · UNIVERSITY OF HOUSTON · PI LIU, XINLI · 2015 to 2019
$523k
Abrogating Nanoparticle-induced Immunosuppression in Tumor MicroenvironmentR15CA192097 · NCI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI LA-BECK, NINH · 2015 to 2015
$453k
Targeting Kidney Cancer-associated CD105 expression with a novel Listeria-based Vaccine ApproachR15CA216205 · NCI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI WOOD, LAURENCE MICHAEL · 2017 to 2017
$377k
NCI NIH HHS P20 CA221729NCI NIH HHS P20 CA221731NCI NIH HHS R15 CA182769NCI NIH HHS R15 CA192097NCI NIH HHS R15 CA216205
6 · The paper itself

Abstract

Liposomal nanoparticles are a heterogeneous group of engineered drug carriers that have tremendous therapeutic potential in the treatment of cancer. They increase tumor drug delivery, significantly attenuate drug toxicity, and protect the drug from degradation. However, two decades after approval of the first nanoparticle-mediated anticancer drug, pegylated liposomal doxorubicin (Doxil), there has yet to be a major shift in cancer treatment paradigms. Only two anticancer nanoparticles are used in the first-line treatment of cancer patients, with all others relegated to the refractory or salvage setting. Herein, we discuss new insights into the mechanisms underlying

Indexed as

cancer nanomedicinesdrug carrierimmunosuppressionliposomenanoparticlestumor immunology

Identifiers

PMID30914953
PMCPMC6422978
OpenAlexW2921674896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.