Evidence map›Paper›PMID 30914918›Full record

ArticleFrontiers in neuroscience2019

Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Recovery Following Spinal Cord Injury via Improvement of the Integrity of the Blood-Spinal Cord Barrier.

Yanhui Lu, Yan Zhou, Ruiyi Zhang, Lulu Wen, Kaimin Wu, Yanfei Li, Yaobing Yao, Ranran Duan, Yanjie Jia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 3 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 3 syntheses or guidelines pooled it, 179 citations in OpenAlex.

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  19. Brain repair mechanisms after cell therapy for stroke.Brain : a journal of neurology · 2024
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yanhui LuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yan ZhouDepartment of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ruiyi ZhangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lulu WenDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Kaimin WuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanfei LiDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yaobing YaoDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ranran DuanDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanjie JiaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cell (MSC) transplantation has been shown to represent a potential treatment for traumatic spinal cord injury (SCI). However, there are several obstacles that need to be overcome before MSCs can be considered for clinical application, such as failure of MSCs to reach the spinal cord lesion core and possible tumor formation. Recent studies have suggested that MSC treatment is beneficial owing to paracrine-secreted factors. Extracellular vesicles are considered to be some of the most valuable paracrine molecules. However, the therapeutic mechanism of extracellular vesicles on spinal cord injury has not been studied clearly. Therefore, our study investigated the effect of systemic administration of extracellular vesicles on the loss of motor function after SCI and examined the potential mechanisms underlying their effects. Disruption of the blood-spinal cord barrier (BSCB) is a crucial factor that can be detrimental to motor function recovery. Pericytes are an important component of the neurovascular unit, and play a pivotal role in maintaining the structural integrity of the BSCB. Our study demonstrated that administration of bone mesenchymal stem cell-derived extracellular vesicles (BMSC-EV) reduced brain cell death, enhanced neuronal survival and regeneration, and improved motor function compared with the administration of BMSC-EV free culture media (EV-free CM). Besides, the BSCB was attenuated and pericyte coverage was significantly decreased

Indexed as

blood spinal cord barrierbone mesenchymal stromal cellsextracellular vesiclesmigrationNF-κBpericytesspinal cord injury

Identifiers

PMID30914918
PMCPMC6423165
OpenAlexW2922260431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.