ArticleScientific reports2019
Effects of sublethal doses of clothianidin and/or V. destructor on honey bee (Apis mellifera) self-grooming behavior and associated gene expression.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Effectiveness of machine learning methods in detecting grooming: a systematic meta-analytic review.Scientific reports · 2025Pooled it
- Effect of Selection for Low and HighPathogens (Basel, Switzerland) · 2025Article
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- Cellular heterogeneity of the developing worker honey bee (Apis mellifera) pupa: a single cell transcriptomics analysis.G3 (Bethesda, Md.) · 2023Article
- Breeding honey bees (Frontiers in insect science · 2023Article
- The Synergistic Effect of Thiamethoxam and Synapsin dsRNA Targets Neurotransmission to Induce Mortality inInternational journal of molecular sciences · 2022Article
- Detection and Concentration of Neonicotinoids and Other Pesticides in Honey from Honey Bee Colonies Located in Regions That Differ in Agricultural Practices: Implications for Human and Bee Health.International journal of environmental research and public health · 2022Article
- Effects of neonicotinoids on honey bee autogrooming behavior against the tracheal mite Acarapis woodi.Ecotoxicology (London, England) · 2022Article
- First insights into the honey bee (Journal of advanced research · 2022Article
- Endogenous Honeybee Gut Microbiota Metabolize the Pesticide Clothianidin.Microorganisms · 2022Article
- Searching beyond the streetlight: Neonicotinoid exposure alters the neurogenomic state of worker honey bees.Ecology and evolution · 2021Article
- Inferring pesticide toxicity to honey bees from a field-based feeding study using a colony model and Bayesian inference.Ecological applications : a publication of the Ecological Society of America · 2021Article
- Honey Bee Proteolytic System and Behavior Parameters under the Influence of an Electric Field at 50 Hz and Variable Intensities for a Long Exposure Time.Animals : an open access journal from MDPI · 2021Article
- Comparative selectivity of nano and commercial formulations of pirimicarb on a target pest, Brevicoryne brassicae, and its predator Chrysoperla carnea.Ecotoxicology (London, England) · 2021Article
- Sublethal concentrations of clothianidin affect honey bee colony growth and hive COScientific reports · 2021Article
- The Power ofFrontiers in physiology · 2021Review
- Chemical Stimulants and Stressors Impact the Outcome of Virus Infection and Immune Gene Expression in Honey Bees (Frontiers in immunology · 2021Article
- Advances and perspectives in selecting resistance traits against the parasitic mite Varroa destructor in honey bees.Genetics, selection, evolution : GSE · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the combined effects of stressors on social immunity of honey bees (Apis mellifera) and related gene expression. The interaction between sublethal doses of a neurotoxin, clothianidin, and the ectoparasite, Varroa destructor, was examined by measuring differentially expressed genes (DEGs) in brains, deformed wing virus (DWV) and the proportion and intensity of self-grooming. Evidence for an interaction was observed between the stressors in a reduction in the proportion of intense groomers. Only the lowest dose of clothianidin alone reduced the proportion of self-groomers and increased DWV levels. V. destructor shared a higher proportion of DEGs with the combined stressors compared to clothianidin, indicating that the effects of V. destructor were more pervasive than those of clothianidin when they were combined. The number of up-regulated DEGs were reduced with the combined stressors compared to clothianidin alone, suggesting an interference with the impacts of clothianidin. Clothianidin and V. destructor affected DEGs from different biological pathways but shared impacts on pathways related to neurodegenerative disorders, like Alzheimer's, which could be related to neurological dysfunction and may explain their negative impacts on grooming. This study shows that the combination of clothianidin and V. destructor resulted in a complex and non-additive interaction.
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