Evidence map›Paper›PMID 30914642›Full record

ArticleNature communications2019

IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling.

Gang Xue, Guangxu Jin, Jing Fang, Yong Lu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. The Potential of the Gut Microbiota and Butyrate to Enhance CAR T-cell Therapy in Non-Hodgkin Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Go to the scene: TJournal for immunotherapy of cancer · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. CD4Trends in cancer · 2024
    Review
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gang XueDepartment of Microbiology & Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Guangxu JinDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jing FangDepartment of Microbiology & Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Yong LuDepartment of Microbiology & Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA. yolu@wakehealth.edu.
Wake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Th9 cells as a promising effector T-cell subset for cancer therapyR00CA190910 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LU, YONG · 2017 to 2019
$747k
Th9 cells as a promising effector T-cell subset for cancer therapyK99CA190910 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI LU, YONG · 2015 to 2016
$185k
NCATS NIH HHS UL1 TR001420NCI NIH HHS K99 CA190910NCI NIH HHS P30 CA012197NCI NIH HHS R00 CA190910
6 · The paper itself

Abstract

IL-9-producing CD4

Indexed as

AnimalsCell DifferentiationCell Line, TumorInterleukin-1Interleukin-1betaInterleukin-4Interleukin-9LymphopoiesisMelanoma, ExperimentalMiceNF-kappa BPhenotypeT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerT-Lymphocyte SubsetsTranscriptomeInterleukin-1Interleukin-1betaInterleukin-4Interleukin-9NF-kappa BTransforming Growth Factor beta

Identifiers

PMID30914642
PMCPMC6435687
OpenAlexW2925224133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.