Evidence map›Paper›PMID 30914509›Full record

ArticlemBio2019

Entry of Polarized Effector Cells into Quiescence Forces HIV Latency.

Curtis Dobrowolski, Saba Valadkhan, Amy C Graham, Meenakshi Shukla, Angela Ciuffi, Amalio Telenti, Jonathan Karn

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. HIV Reservoirs and Treatment Strategies toward Curing HIV Infection.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Curtis DobrowolskiDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Saba ValadkhanDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Amy C GrahamDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Meenakshi ShuklaDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Angela CiuffiInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Amalio TelentiDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Jonathan KarnDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA jonathan.karn@case.edu.
Case Western Reserve University · USUniversity School · USScripps Research Institute · USUniversity of Lausanne · CH

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
Using NK Cells to eliminate the latent HIV reservoirU19AI096113 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOELK, CHRISTOPHER H · 2011 to 2015
$39.5M
Manipulating Epigenetic Control Mechanisms to Control HIV TranscriptionDP1DA028869 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI KARN, JONATHAN · 2009 to 2013
$3.9M
Identification and eliminationof HIV reservoirs in oral lymphoid tissues by engineered NK cells.R01DE025464 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI KARN, JONATHAN · 2015 to 2019
$3.8M
Drugs of abuse and the epigenetic and signaling pathways controlling HIV latencyR01DA036171 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI GOLDSTEIN, HARRIS, HARVEY, BRANDON K · 2013 to 2017
$3.6M
Role of non-coding RNA in establishing and maintaining HIV latencyR01AI120204 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KARN, JONATHAN · 2015 to 2017
$594k
Defining the lncRNA-mediated cis regulatory networks that control HIV life cycle in T cellsR21AI127252 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI VALADKHAN, SABA · 2016 to 2017
$436k
NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI120204NIAID NIH HHS R21 AI127252NIAID NIH HHS U19 AI096113NIDA NIH HHS DP1 DA028869NIDCR NIH HHS R01 DE025464
6 · The paper itself

Abstract

The latent HIV reservoir is generated following HIV infection of activated effector CD4 T cells, which then transition to a memory phenotype. Here, we describe an

Indexed as

Virus ActivationVirus LatencyCD4-Positive T-LymphocytesCells, CulturedCytokinesFlow CytometryHIVHIV InfectionsHumansModels, BiologicalT-Lymphocyte SubsetsCytokinescell quiescenceHIV latencyHIV reservoirhuman immunodeficiency virusP-TEFb

Identifiers

PMID30914509
PMCPMC6437053
OpenAlexW2923624122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.