Evidence map›Paper›PMID 30914502›Full record

ArticlemBio2019

A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity.

Kimberly A Walker, Taryn A Miner, Michelle Palacios, Dominika Trzilova, Daniel R Frederick, Christopher A Broberg, Victoria E Sepúlveda, Joshua D Quinn, Virginia L Miller

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.

  1. Prevalence and risk factors ofFrontiers in veterinary science · 2023
    Pooled it
  2. Article
  3. Article
  4. Hypermucoviscosity inJournal of bacteriology · 2026
    Review
  5. Sedative choice altersInfection and immunity · 2026
    Article
  6. Article
  7. Genomic Analysis of HypervirulentIranian journal of biotechnology · 2026
    Article
  8. Article
  9. Article
  10. Infection and immunity · 2026
    Article
  11. Article
  12. Materials today. Bio · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Connections betweenInfection and immunity · 2026
    Article
  17. Article
  18. <p>Molecular medicine reports · 2026
    Review
  19. Article
  20. The acquisition ofmBio · 2026
    Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kimberly A WalkerDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA kawalker@med.unc.edu.
Taryn A MinerDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Michelle PalaciosDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Dominika TrzilovaDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Daniel R FrederickDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Christopher A BrobergDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Victoria E SepúlvedaDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0003-2085-9667
Joshua D QuinnDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Virginia L MillerDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · US

Funding

Regulators of Klebsiella VirulenceR21AI132925 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MILLER, VIRGINIA L · 2018 to 2019
$428k
NIAID NIH HHS R21 AI132925
6 · The paper itself

Abstract

The polysaccharide capsule is an essential virulence factor for

Indexed as

Gene Expression Regulation, BacterialMutationAnimalsBacterial CapsulesBacterial ProteinsDisease Models, AnimalGene DeletionGene Regulatory NetworksKlebsiella InfectionsKlebsiella pneumoniaeMicePhenotypePneumonia, BacterialVirulenceViscosityBacterial ProteinsRcsB protein, BacteriaRmpA protein, Klebsiella pneumoniaecapsular polysaccharideHMVhypervirulentRmpARmpC

Identifiers

PMID30914502
PMCPMC6437046
OpenAlexW2923573041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.