Evidence map›Paper›PMID 30914440›Full record

ArticleThe Biochemical journal2019

Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1.

Zhanjun Hou, Carrie O'Connor, Josephine Frühauf, Steve Orr, Seongho Kim, Aleem Gangjee, Larry H Matherly

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Biochemical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Biology and therapeutic applications of the proton-coupled folate transporter.Expert opinion on drug metabolism & toxicology · 2022
    Article
  2. The evolving biology of the proton-coupled folate transporter: New insights into regulation, structure, and mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Review
  3. Altered Mitochondrial Dynamics, Biogenesis, and Functions in the Paclitaxel-Resistant Lung Adenocarcinoma Cell Line A549/Taxol.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhanjun HouMolecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, U.S.A.ORCID 0000-0001-5631-5202
Carrie O'ConnorDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, U.S.A.
Josephine FrühaufDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, U.S.A.
Steve OrrDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, U.S.A.
Seongho KimMolecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, U.S.A.
Aleem GangjeeDivision of Medicinal Chemistry, Duquesne University, Pittsburgh, PA, U.S.A.
Larry H MatherlyMolecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, U.S.A. houz@karmanos.org matherly@karmanos.org.
Wayne State University · USDuquesne University · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
MOLECULAR REGULATION OF FOLATE AND ANTIFOLATE TRANSPORTR01CA053535 · NCI · WAYNE STATE UNIVERSITY · PI HOU, ZHANJUN, MATHERLY, LARRY H · 1993 to 2024
$6.3M
Discovery of novel PCFT-targeted agentsR01CA152316 · NCI · WAYNE STATE UNIVERSITY · PI GANGJEE, ALEEM, MATHERLY, LARRY H · 2011 to 2015
$2.3M
Purine Synthesis Inhibitors with Selective Folate Receptor Tumor TransportR01CA166711 · NCI · DUQUESNE UNIVERSITY · PI DANN, CHARLES E., GANGJEE, ALEEM · 2013 to 2015
$1.7M
NCI NIH HHS P30 CA022453NCI NIH HHS R01 CA053535NCI NIH HHS R01 CA152316NCI NIH HHS R01 CA166711
6 · The paper itself

Abstract

Tumors can be therapeutically targeted with novel antifolates (e.g.

Indexed as

Gene Expression Regulation, NeoplasticResponse ElementsAnimalsDrosophila melanogasterHeLa CellsHep G2 CellsHumansKruppel-Like Transcription FactorsNeoplasm ProteinsNeoplasmsNuclear Respiratory Factor 1Proton-Coupled Folate TransporterSp1 Transcription FactorKLF15 protein, humanKruppel-Like Transcription FactorsNeoplasm ProteinsNRF1 protein, humanNuclear Respiratory Factor 1Proton-Coupled Folate TransporterSLC46A1 protein, humanSp1 Transcription Factor

Identifiers

PMID30914440
PMCPMC6794195
OpenAlexW2923285365

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.